Table 3 Performance characteristics of ELISA for IgG and IgM to CL and β2GPI
From: Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay
Sensitivity | 95% CI | specificity | 95% CI | +LR | 95% CI | -LR | 95% CI | |
|---|---|---|---|---|---|---|---|---|
anti-CL IgG | 52.9 | 41.8 to 63.9 | 98.6 | 95.1 to 99.8 | 38.1 | 9.5 to 153.2 | 0.5 | 0.4 to 0.6 |
anti-CL IgM | 37.6 | 27.4 to 48.8 | 99.3 | 96.2 to 100.0 | 54.2 | 7.5 to 309.6 | 0.6 | 0.5 to 0.7 |
anti-β2 GPI IgG | 31.8 | 22.1 to 42.2 | 100.0 | 97.5 to 100.0 | ∞ | 0.7 | 0.6 to 0.8 | |
anti-β2 GPI IgM | 38.8 | 28.4 to 50.0 | 97.2 | 93.0 to 99.2 | 14.0 | 5.1 to 38.1 | 0.6 | 0.5 to 0.8 |