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Table 3 Performance characteristics of ELISA for IgG and IgM to CL and β2GPI

From: Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay

  Sensitivity 95% CI specificity 95% CI +LR 95% CI -LR 95% CI
anti-CL IgG 52.9 41.8 to 63.9 98.6 95.1 to 99.8 38.1 9.5 to 153.2 0.5 0.4 to 0.6
anti-CL IgM 37.6 27.4 to 48.8 99.3 96.2 to 100.0 54.2 7.5 to 309.6 0.6 0.5 to 0.7
anti-β2 GPI IgG 31.8 22.1 to 42.2 100.0 97.5 to 100.0   0.7 0.6 to 0.8
anti-β2 GPI IgM 38.8 28.4 to 50.0 97.2 93.0 to 99.2 14.0 5.1 to 38.1 0.6 0.5 to 0.8
  1. Investigating 85 APS patients, 65 DC patients, and 79 NHS, sensitivity, specificity, and likelihood ratios were calculated using a cut-off of 10 U/ml for all ELISA
  2. anti-β2 GPI, anti-beta2-glycoprotein I; anti-CL, anti-cardiolipin; +LR, positive likelihood ratio; -LR, negative likelihood ratio.