Table 5 Comparison of the performance characteristics of ELISA and MLDAf
From: Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay
Sensitivity | 95% CI | specificity | 95% CI | +LR | 95% CI | -LR | 95% CI | |
|---|---|---|---|---|---|---|---|---|
at least one aPL antibody by ELISA | 58.8 | 47.6 to 69.4 | 95.8 | 91.1 to 98.5 | 14.1 | 6.3 to 31.5 | 0.4 | 0.3 to 0.6 |
at least one aPL antibody by MLDA | 67.9 | 56.8 to 77.6 | 89.6 | 83.4 to 94.0 | 6.5 | 4.0 to 10.8 | 0.4 | 0.3 to 0.5 |
at least one aPL IgG or at least three aPL IgM by MLDA | 67.1 | 56.0 to 76.9 | 96.5 | 92.1 to 98.9 | 19.3 | 8.1 to 46.3 | 0.3 | 0.2 to 0.5 |