Figure 6
From: A targeted lipidomics approach to the study of eicosanoid release in synovial joints
Synovial fluid hydroxyeicosatetraenoic acid (HETE) (a-d) and leukotriene B 4 (LTB 4 ) (e) concentrations during lipopolysaccharide (LPS)-induced synovitis. Horses were treated with a non-steroidal anti-inflammatory drug (NSAID) (meloxicam, 0.6 mg/kg once a day by mouth; n = 6) or placebo (n = 6) starting at 2 hours after LPS injection for a total of seven treatments. Individual HETEs respond differentially to LPS and NSAID treatment. Boxes depict median and interquartile range; whiskers denote minimum and maximum values. *P < 0.05.