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Table 2 Drugs used to treat arthritis

From: Characterization of a novel and spontaneous mouse model of inflammatory arthritis

Type of drug Name of drug Use
Drugs that affect symptoms of the disease (analgesics) Acetaminophen Aspirin Relieves pain Reduces inflammation and relieves pain
Oral nonsteroidal anti-inflammatory drugs (NSAIDs) Diclofenac Diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, phenylbutazone, piroxicam, sulindac, tolmetin Reduces inflammation and relieves pain All NSAIDs treat the symptoms and decrease inflammation but do not alter the course of the disease
COX-2 inhibitors Celecoxib, valdecoxib Reduces inflammation and relieves pain
Narcotic/analgesics Propoxyphene Tramadol Relieves pain Relieves pain
Corticosteroids Methylprednisolone, prednisone, injectable corticosteroids Suppresses inflammation in severe organ disease or life-threatening disease
Disease-modifying antirheumatic drugs (DMARDs)a Auranofin (oral gold), cyclosporine, gold salts (injectable), hydroxychloroquine, leflunomide, methotrexate, penicillamine, sulfasalazine All DMARDs can slow progression of joint damage as well as gradually decrease pain and swelling
Biologics   
   Anti-TNF compounds Adalimumab, etanercept, infliximab, certolizumab, golimumab Suppresses inflammation and inhibit the progress of joint damage
   IL-1 inhibitor Anakinra Treats moderate to severe RA in people who do not respond to DMARDs
   B-cell-depleting agent Rituximab Treats RA unresponsive to TNF inhibitors
   T-cell co-stimulation antagonist Abatacept Treats RA unresponsive to DMARD therapy
   IL-6 antagonist Tocilizumab Treats RA unresponsive to TNF inhibitors
  1. COX, cyclooxygenase; DMARD, disease-modifying anti-rheumatic drug; IL, interleukin; RA, rheumatoid arthritis; TNF, tumor necrosis factor.