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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts

Figure 1

Evaluation of MMP-3 production in OA and RA FLS. Human fibroblast-like synoviocytes (FLS) isolated from either (a), osteoarthritis (OA), or (b), rheumatoid arthritis (RA) synovial tissues were stimulated with pro-inflammatory cytokine IL-1β (10 ng/ml) in the presence and absence of IDR peptides. Tissue-culture supernatants were monitored for MMP-3 production by ELISA after 24-hour stimulation. Results shown are an average of at least three independent biologic experiments performed with cells isolated from synovial tissues obtained from independent donors ± standard error (*P < 0.05). IDR, innate defence regulator; IL, interleukin; MMP-3, matrix metalloproteinase-3.

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