TY - JOUR AU - Driban, J. B. AU - Sitler, M. R. AU - Barbe, M. F. AU - Balasubramanian, E. PY - 2010 DA - 2010// TI - Is osteoarthritis a heterogeneous disease that can be stratified into subsets? JO - Clin Rheumatol VL - 29 UR - https://doi.org/10.1007/s10067-009-1301-1 DO - 10.1007/s10067-009-1301-1 ID - Driban2010 ER - TY - JOUR AU - Abramson, S. B. AU - Attur, M. PY - 2009 DA - 2009// TI - Developments in the scientific understanding of osteoarthritis JO - Arthritis Res Ther VL - 11 UR - https://doi.org/10.1186/ar2655 DO - 10.1186/ar2655 ID - Abramson2009 ER - TY - JOUR AU - Knauper, V. AU - Lopez-Otin, C. AU - Smith, B. AU - Knight, G. AU - Murphy, G. PY - 1996 DA - 1996// TI - Biochemical characterization of human collagenase-3 JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.3.1544 DO - 10.1074/jbc.271.3.1544 ID - Knauper1996 ER - TY - JOUR AU - Tetlow, L. C. AU - Adlam, D. J. AU - Woolley, D. E. PY - 2001 DA - 2001// TI - Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes JO - Arthritis Rheum VL - 44 UR - https://doi.org/3.0.CO;2-C DO - 3.0.CO;2-C ID - Tetlow2001 ER - TY - JOUR AU - Loeser, R. F. AU - Chubinskaya, S. AU - Pacione, C. AU - Im, H. J. PY - 2005 DA - 2005// TI - Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes JO - Arthritis Rheum VL - 52 UR - https://doi.org/10.1002/art.21472 DO - 10.1002/art.21472 ID - Loeser2005 ER - TY - JOUR AU - Bauge, C. AU - Legendre, F. AU - Leclercq, S. AU - Elissalde, J. M. AU - Pujol, J. P. AU - Galera, P. AU - Boumediene, K. PY - 2007 DA - 2007// TI - Interleukin-1beta impairment of transforming growth factor beta1 signaling by down-regulation of transforming growth factor beta receptor type II and up-regulation of Smad7 in human articular chondrocytes JO - Arthritis Rheum VL - 56 UR - https://doi.org/10.1002/art.22840 DO - 10.1002/art.22840 ID - Bauge2007 ER - TY - JOUR AU - Kaiser, M. AU - Haag, J. AU - Soder, S. AU - Bau, B. AU - Aigner, T. PY - 2004 DA - 2004// TI - Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta JO - Arthritis Rheum VL - 50 UR - https://doi.org/10.1002/art.20750 DO - 10.1002/art.20750 ID - Kaiser2004 ER - TY - JOUR AU - van der Kraan, P. M. AU - van den Berg, W. B. PY - 2000 DA - 2000// TI - Anabolic and destructive mediators in osteoarthritis JO - Curr Opin Clin Nutr Metab Care VL - 3 UR - https://doi.org/10.1097/00075197-200005000-00007 DO - 10.1097/00075197-200005000-00007 ID - van der Kraan2000 ER - TY - JOUR AU - Ellman, M. B. AU - An, H. S. AU - Muddasani, P. AU - Im, H. J. PY - 2008 DA - 2008// TI - Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis JO - Gene VL - 420 UR - https://doi.org/10.1016/j.gene.2008.04.019 DO - 10.1016/j.gene.2008.04.019 ID - Ellman2008 ER - TY - JOUR AU - Vincent, T. AU - Hermansson, M. AU - Bolton, M. AU - Wait, R. AU - Saklatvala, J. PY - 2002 DA - 2002// TI - Basic FGF mediates an immediate response of articular cartilage to mechanical injury JO - Proc Natl Acad Sci USA VL - 99 UR - https://doi.org/10.1073/pnas.122033199 DO - 10.1073/pnas.122033199 ID - Vincent2002 ER - TY - JOUR AU - Wang, X. AU - Manner, P. A. AU - Horner, A. AU - Shum, L. AU - Tuan, R. S. AU - Nuckolls, G. H. PY - 2004 DA - 2004// TI - Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage JO - Osteoarthritis Cartilage VL - 12 UR - https://doi.org/10.1016/j.joca.2004.08.008 DO - 10.1016/j.joca.2004.08.008 ID - Wang2004 ER - TY - JOUR AU - Schmal, H. AU - Zwingmann, J. AU - Fehrenbach, M. AU - Finkenzeller, G. AU - Stark, G. B. AU - Sudkamp, N. P. AU - Hartl, D. AU - Mehlhorn, A. T. PY - 2007 DA - 2007// TI - bFGF influences human articular chondrocyte differentiation JO - Cytotherapy VL - 9 UR - https://doi.org/10.1080/14653240601182846 DO - 10.1080/14653240601182846 ID - Schmal2007 ER - TY - JOUR AU - Stewart, K. AU - Pabbruwe, M. AU - Dickinson, S. AU - Sims, T. AU - Hollander, A. P. AU - Chaudhuri, J. B. PY - 2007 DA - 2007// TI - The effect of growth factor treatment on meniscal chondrocyte proliferation and differentiation on polyglycolic acid scaffolds JO - Tissue Eng VL - 13 UR - https://doi.org/10.1089/ten.2006.0242 DO - 10.1089/ten.2006.0242 ID - Stewart2007 ER - TY - JOUR AU - Sonal, D. PY - 2001 DA - 2001// TI - Prevention of IGF-1 and TGFbeta stimulated type II collagen and decorin expression by bFGF and identification of IGF-1 mRNA transcripts in articular chondrocytes JO - Matrix Biol VL - 20 UR - https://doi.org/10.1016/S0945-053X(01)00140-8 DO - 10.1016/S0945-053X(01)00140-8 ID - Sonal2001 ER - TY - JOUR AU - Sah, R. L. AU - Trippel, S. B. AU - Grodzinsky, A. J. PY - 1996 DA - 1996// TI - Differential effects of serum, insulin-like growth factor-I, and fibroblast growth factor-2 on the maintenance of cartilage physical properties during long-term culture JO - J Orthop Res VL - 14 UR - https://doi.org/10.1002/jor.1100140109 DO - 10.1002/jor.1100140109 ID - Sah1996 ER - TY - JOUR AU - Sawaji, Y. AU - Hynes, J. AU - Vincent, T. AU - Saklatvala, J. PY - 2008 DA - 2008// TI - Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage JO - Arthritis Rheum VL - 58 UR - https://doi.org/10.1002/art.24025 DO - 10.1002/art.24025 ID - Sawaji2008 ER - TY - JOUR AU - Chia, S. L. AU - Sawaji, Y. AU - Burleigh, A. AU - McLean, C. AU - Inglis, J. AU - Saklatvala, J. AU - Vincent, T. PY - 2009 DA - 2009// TI - Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24654 DO - 10.1002/art.24654 ID - Chia2009 ER - TY - JOUR AU - Im, H. J. AU - Muddasani, P. AU - Natarajan, V. AU - Schmid, T. M. AU - Block, J. A. AU - Davis, F. AU - van Wijnen, A. J. AU - Loeser, R. F. PY - 2007 DA - 2007// TI - Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M609040200 DO - 10.1074/jbc.M609040200 ID - Im2007 ER - TY - JOUR AU - Muddasani, P. AU - Norman, J. C. AU - Ellman, M. AU - van Wijnen, A. J. AU - Im, H. J. PY - 2007 DA - 2007// TI - Basic fibroblast growth factor activates the MAPK and NFkappaB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M706508200 DO - 10.1074/jbc.M706508200 ID - Muddasani2007 ER - TY - JOUR AU - Degnin, C. R. AU - Laederich, M. B. AU - Horton, W. A. PY - 2010 DA - 2010// TI - FGFs in endochondral skeletal development JO - J Cell Biochem VL - 110 UR - https://doi.org/10.1002/jcb.22629 DO - 10.1002/jcb.22629 ID - Degnin2010 ER - TY - JOUR AU - Murphy, G. AU - Knauper, V. AU - Cowell, S. AU - Hembry, R. AU - Stanton, H. AU - Butler, G. AU - Freije, J. AU - Pendas, A. M. AU - Lopez-Otin, C. PY - 1999 DA - 1999// TI - Evaluation of some newer matrix metalloproteinases JO - Ann N Y Acad Sci VL - 878 UR - https://doi.org/10.1111/j.1749-6632.1999.tb07672.x DO - 10.1111/j.1749-6632.1999.tb07672.x ID - Murphy1999 ER - TY - JOUR AU - Woei Ng, K. AU - Speicher, T. AU - Dombrowski, C. AU - Helledie, T. AU - Haupt, L. M. AU - Nurcombe, V. AU - Cool, S. M. PY - 2007 DA - 2007// TI - Osteogenic differentiation of murine embryonic stem cells is mediated by fibroblast growth factor receptors JO - Stem Cells Dev VL - 16 UR - https://doi.org/10.1089/scd.2006.0044 DO - 10.1089/scd.2006.0044 ID - Woei Ng2007 ER - TY - JOUR AU - Muehleman, C. AU - Bareither, D. AU - Huch, K. AU - Cole, A. A. AU - Kuettner, K. E. PY - 1997 DA - 1997// TI - Prevalence of degenerative morphological changes in the joints of the lower extremity JO - Osteoarthritis Cartilage VL - 5 UR - https://doi.org/10.1016/S1063-4584(97)80029-5 DO - 10.1016/S1063-4584(97)80029-5 ID - Muehleman1997 ER - TY - JOUR AU - Im, H. J. AU - Pacione, C. AU - Chubinskaya, S. AU - Van Wijnen, A. J. AU - Sun, Y. AU - Loeser, R. F. PY - 2003 DA - 2003// TI - Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M302048200 DO - 10.1074/jbc.M302048200 ID - Im2003 ER - TY - JOUR AU - Hauselmann, H. J. AU - Aydelotte, M. B. AU - Schumacher, B. L. AU - Kuettner, K. E. AU - Gitelis, S. H. AU - Thonar, E. J. PY - 1992 DA - 1992// TI - Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads JO - Matrix VL - 12 UR - https://doi.org/10.1016/S0934-8832(11)80053-3 DO - 10.1016/S0934-8832(11)80053-3 ID - Hauselmann1992 ER - TY - JOUR AU - Loeser, R. F. AU - Todd, M. D. AU - Seely, B. L. PY - 2003 DA - 2003// TI - Prolonged treatment of human osteoarthritic chondrocytes with insulin-like growth factor-I stimulates proteoglycan synthesis but not proteoglycan matrix accumulation in alginate cultures JO - J Rheumatol VL - 30 ID - Loeser2003 ER - TY - JOUR AU - Farndale, R. W. AU - Sayers, C. A. AU - Barrett, A. J. PY - 1982 DA - 1982// TI - A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures JO - Connect Tissue Res VL - 9 UR - https://doi.org/10.3109/03008208209160269 DO - 10.3109/03008208209160269 ID - Farndale1982 ER - TY - JOUR AU - Enobakhare, B. O. AU - Bader, D. L. AU - Lee, D. A. PY - 1996 DA - 1996// TI - Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue JO - Anal Biochem VL - 243 UR - https://doi.org/10.1006/abio.1996.0502 DO - 10.1006/abio.1996.0502 ID - Enobakhare1996 ER - TY - JOUR AU - Pulai, J. I. AU - Chen, H. AU - Im, H. J. AU - Kumar, S. AU - Hanning, C. AU - Hegde, P. S. AU - Loeser, R. F. PY - 2005 DA - 2005// TI - NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments JO - J Immunol VL - 174 UR - https://doi.org/10.4049/jimmunol.174.9.5781 DO - 10.4049/jimmunol.174.9.5781 ID - Pulai2005 ER - TY - JOUR AU - Loeser, R. F. AU - Yammani, R. R. AU - Carlson, C. S. AU - Chen, H. AU - Cole, A. AU - Im, H. J. AU - Bursch, L. S. AU - Yan, S. D. PY - 2005 DA - 2005// TI - Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis JO - Arthritis Rheum VL - 52 UR - https://doi.org/10.1002/art.21199 DO - 10.1002/art.21199 ID - Loeser2005 ER - TY - JOUR AU - Kim, J. H. AU - Glant, T. T. AU - Lesley, J. AU - Hyman, R. AU - Mikecz, K. PY - 2000 DA - 2000// TI - Adhesion of lymphoid cells to CD44-specific substrata: the consequences of attachment depend on the ligand JO - Exp Cell Res VL - 256 UR - https://doi.org/10.1006/excr.2000.4852 DO - 10.1006/excr.2000.4852 ID - Kim2000 ER - TY - JOUR AU - Zhang, X. AU - Ibrahimi, O. A. AU - Olsen, S. K. AU - Umemori, H. AU - Mohammadi, M. AU - Ornitz, D. M. PY - 2006 DA - 2006// TI - Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M601252200 DO - 10.1074/jbc.M601252200 ID - Zhang2006 ER - TY - JOUR AU - Davidson, D. AU - Blanc, A. AU - Filion, D. AU - Wang, H. AU - Plut, P. AU - Pfeffer, G. AU - Buschmann, M. D. AU - Henderson, J. E. PY - 2005 DA - 2005// TI - Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M410148200 DO - 10.1074/jbc.M410148200 ID - Davidson2005 ER - TY - JOUR AU - Ellsworth, J. L. AU - Berry, J. AU - Bukowski, T. AU - Claus, J. AU - Feldhaus, A. AU - Holderman, S. AU - Holdren, M. S. AU - Lum, K. D. AU - Moore, E. E. AU - Raymond, F. AU - Ren, H. AU - Shea, P. AU - Sprecher, C. AU - Storey, H. AU - Thompson, D. L. AU - Waggie, K. AU - Yao, L. AU - Fernandes, R. J. AU - Eyre, D. R. AU - Hughes, S. D. PY - 2002 DA - 2002// TI - Fibroblast growth factor-18 is a trophic factor for mature chondrocytes and their progenitors JO - Osteoarthritis Cartilage VL - 10 UR - https://doi.org/10.1053/joca.2002.0514 DO - 10.1053/joca.2002.0514 ID - Ellsworth2002 ER - TY - JOUR AU - Mohammadi, M. AU - McMahon, G. AU - Sun, L. AU - Tang, C. AU - Hirth, P. AU - Yeh, B. K. AU - Hubbard, S. R. AU - Schlessinger, J. PY - 1997 DA - 1997// TI - Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors JO - Science VL - 276 UR - https://doi.org/10.1126/science.276.5314.955 DO - 10.1126/science.276.5314.955 ID - Mohammadi1997 ER - TY - JOUR AU - Im, H. J. AU - Li, X. AU - Muddasani, P. AU - Kim, G. H. AU - Davis, F. AU - Rangan, J. AU - Forsyth, C. B. AU - Ellman, M. AU - Thonar, E. J. PY - 2008 DA - 2008// TI - Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes JO - J Cell Physiol VL - 215 UR - https://doi.org/10.1002/jcp.21317 DO - 10.1002/jcp.21317 ID - Im2008 ER - TY - JOUR AU - Valverde-Franco, G. AU - Binette, J. S. AU - Li, W. AU - Wang, H. AU - Chai, S. AU - Laflamme, F. AU - Tran-Khanh, N. AU - Quenneville, E. AU - Meijers, T. AU - Poole, A. R. AU - Mort, J. S. AU - Buschmann, M. D. AU - Henderson, J. E. PY - 2006 DA - 2006// TI - Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice JO - Hum Mol Genet VL - 15 UR - https://doi.org/10.1093/hmg/ddl100 DO - 10.1093/hmg/ddl100 ID - Valverde-Franco2006 ER - TY - JOUR AU - Neuhold, L. A. AU - Killar, L. AU - Zhao, W. AU - Sung, M. L. AU - Warner, L. AU - Kulik, J. AU - Turner, J. AU - Wu, W. AU - Billinghurst, C. AU - Meijers, T. AU - Poole, A. R. AU - Babij, P. AU - DeGennaro, L. J. PY - 2001 DA - 2001// TI - Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice JO - J Clin Invest VL - 107 UR - https://doi.org/10.1172/JCI10564 DO - 10.1172/JCI10564 ID - Neuhold2001 ER - TY - JOUR AU - Martel-Pelletier, J. AU - Boileau, C. AU - Pelletier, J. P. AU - Roughley, P. J. PY - 2008 DA - 2008// TI - Cartilage in normal and osteoarthritis conditions JO - Best Pract Res Clin Rheumatol VL - 22 UR - https://doi.org/10.1016/j.berh.2008.02.001 DO - 10.1016/j.berh.2008.02.001 ID - Martel-Pelletier2008 ER - TY - JOUR AU - Kaul, G. AU - Cucchiarini, M. AU - Arntzen, D. AU - Zurakowski, D. AU - Menger, M. D. AU - Kohn, D. AU - Trippel, S. B. AU - Madry, H. PY - 2006 DA - 2006// TI - Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo JO - J Gene Med VL - 8 UR - https://doi.org/10.1002/jgm.819 DO - 10.1002/jgm.819 ID - Kaul2006 ER - TY - JOUR AU - Malfait, A. M. AU - Liu, R. Q. AU - Ijiri, K. AU - Komiya, S. AU - Tortorella, M. D. PY - 2002 DA - 2002// TI - Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M200431200 DO - 10.1074/jbc.M200431200 ID - Malfait2002 ER - TY - JOUR AU - Glasson, S. S. AU - Askew, R. AU - Sheppard, B. AU - Carito, B. AU - Blanchet, T. AU - Ma, H. L. AU - Flannery, C. R. AU - Peluso, D. AU - Kanki, K. AU - Yang, Z. AU - Majumdar, M. K. AU - Morris, E. A. PY - 2005 DA - 2005// TI - Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis JO - Nature VL - 434 UR - https://doi.org/10.1038/nature03369 DO - 10.1038/nature03369 ID - Glasson2005 ER - TY - JOUR AU - Weksler, N. B. AU - Lunstrum, G. P. AU - Reid, E. S. AU - Horton, W. A. PY - 1999 DA - 1999// TI - Differential effects of fibroblast growth factor (FGF) 9 and FGF2 on proliferation, differentiation and terminal differentiation of chondrocytic cells in vitro JO - Biochem J VL - 342 Pt 3 UR - https://doi.org/10.1042/bj3420677 DO - 10.1042/bj3420677 ID - Weksler1999 ER - TY - JOUR AU - Goldring, M. B. AU - Goldring, S. R. PY - 2007 DA - 2007// TI - Osteoarthritis JO - J Cell Physiol VL - 213 UR - https://doi.org/10.1002/jcp.21258 DO - 10.1002/jcp.21258 ID - Goldring2007 ER - TY - JOUR AU - Im, H. J. AU - Kim, J. S. AU - Li, X. AU - Kotwal, N. AU - Sumner, D. R. AU - van Wijnen, A. J. AU - Davis, F. J. AU - Yan, D. AU - Levine, B. AU - Henry, J. L. AU - Desevre, J. AU - Kroin, J. S. PY - 2010 DA - 2010// TI - Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model JO - Arthritis Rheum VL - 62 UR - https://doi.org/10.1002/art.27608 DO - 10.1002/art.27608 ID - Im2010 ER - TY - JOUR AU - Li, X. AU - An, H. S. AU - Ellman, M. AU - Phillips, F. AU - Thonar, E. J. AU - Park, D. K. AU - Udayakumar, R. K. AU - Im, H. J. PY - 2008 DA - 2008// TI - Action of fibroblast growth factor-2 on the intervertebral disc JO - Arthritis Res Ther VL - 10 UR - https://doi.org/10.1186/ar2407 DO - 10.1186/ar2407 ID - Li2008 ER -