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Table 1 Demographic and clinical data in early RA at baseline (T0) and after five years (T5)

From: Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study

Variables

T0 (n= 700)

T5 (n= 442)

Sex, f/m

481/219

301/141

Age at onset of symptoms (years)

55.2 (14.3)

55.1 (14.2)

Duration of symptoms at inclusion (mo)

6.6 (3.3)

6.7 (3.2)

RF, n (%)

489 (76.4)

na

ANA, n (%)

130 (25.0)

na

Anti-CCP, n (%)

373 (67.8)

na

SE, n (%)

330 (56.9)

na

PTPN22 Tvariant, n (%)

167 (34.0)

na

ESR (mm)

31.5 (23.7)

20.0 (19.9)***

CRP (mg/l)

22.0 (24.6)

11.1 (14.3)***

DAS281

4.8 (1.4)

3.2 (1.3)***

HAQ1

0.9 (0.6)

0.6 (0.52)***

Tender joints1

6.7 (5.8)

2.6 (3.7)***

Swollen joints1

7.4 (5.2)

3.2 (4.1)***

VAS pain (mm)1

44.5 (25.2)

28.7 (20.7)***

VAS global (mm) 1

45.3 (24.9)

29.8 (20.6)***

AUC DAS28 (6 mo)1,2

-

25.8 (7.1)

AUC DAS28 (12 mo)1,2

-

47.2 (13.5)

AUC DAS28 (24 mo)1,2

-

87.5 (26.0)

Extra-articular disease, n (%)3

-

21 (3.0)

Presence of nodules, n (%)

-

78 (20.7)

  1. Mean (S.D.) or n (%).
  2. *** P < 0.001, ** P < 0.01, paired t-test, for all patients who had reached the five-year follow-up, that is, who had data at both baseline (T0) and at follow-up (T5). NA, not analysed
  3. 1 Regularly collected data from the RA-registry for 314 patients.
  4. 2 AUC for DAS28 6, 12 and 24 months after inclusion.
  5. 3 Criteria used for severe extra-articular manifestations: pericarditis, pleuritis, interstitial lung disease, Felty's syndrome, neuropathy, scleritis/episcleritis, glomerulonephritis, major cutaneous vasculitis and vasculitis involving other organs [26]. RA, rheumatoid arthritis; RF, rheumatoid factor; ANA, anti-nuclear antibodies; Anti-CCP, anti-cyclic citrullinated peptide/protein; SE, shared epitope; PTPN22, protein tyrosine phosphatise nonreceptor type 22; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; DAS28, disease activity score; HAQ, Health Assessment Questionnaire; VAS, visual analogous scale; AUC, area under the curve.