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Table 1 Demographic and clinical data in early RA at baseline (T0) and after five years (T5)

From: Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study

Variables T0 (n= 700) T5 (n= 442)
Sex, f/m 481/219 301/141
Age at onset of symptoms (years) 55.2 (14.3) 55.1 (14.2)
Duration of symptoms at inclusion (mo) 6.6 (3.3) 6.7 (3.2)
RF, n (%) 489 (76.4) na
ANA, n (%) 130 (25.0) na
Anti-CCP, n (%) 373 (67.8) na
SE, n (%) 330 (56.9) na
PTPN22 Tvariant, n (%) 167 (34.0) na
ESR (mm) 31.5 (23.7) 20.0 (19.9)***
CRP (mg/l) 22.0 (24.6) 11.1 (14.3)***
DAS281 4.8 (1.4) 3.2 (1.3)***
HAQ1 0.9 (0.6) 0.6 (0.52)***
Tender joints1 6.7 (5.8) 2.6 (3.7)***
Swollen joints1 7.4 (5.2) 3.2 (4.1)***
VAS pain (mm)1 44.5 (25.2) 28.7 (20.7)***
VAS global (mm) 1 45.3 (24.9) 29.8 (20.6)***
AUC DAS28 (6 mo)1,2 - 25.8 (7.1)
AUC DAS28 (12 mo)1,2 - 47.2 (13.5)
AUC DAS28 (24 mo)1,2 - 87.5 (26.0)
Extra-articular disease, n (%)3 - 21 (3.0)
Presence of nodules, n (%) - 78 (20.7)
  1. Mean (S.D.) or n (%).
  2. *** P < 0.001, ** P < 0.01, paired t-test, for all patients who had reached the five-year follow-up, that is, who had data at both baseline (T0) and at follow-up (T5). NA, not analysed
  3. 1 Regularly collected data from the RA-registry for 314 patients.
  4. 2 AUC for DAS28 6, 12 and 24 months after inclusion.
  5. 3 Criteria used for severe extra-articular manifestations: pericarditis, pleuritis, interstitial lung disease, Felty's syndrome, neuropathy, scleritis/episcleritis, glomerulonephritis, major cutaneous vasculitis and vasculitis involving other organs [26]. RA, rheumatoid arthritis; RF, rheumatoid factor; ANA, anti-nuclear antibodies; Anti-CCP, anti-cyclic citrullinated peptide/protein; SE, shared epitope; PTPN22, protein tyrosine phosphatise nonreceptor type 22; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; DAS28, disease activity score; HAQ, Health Assessment Questionnaire; VAS, visual analogous scale; AUC, area under the curve.