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Table 1 Studies of carotid intima-media thickness in systemic sclerosis

From: Cardiovascular disease in systemic sclerosis - an emerging association?

Reference Total SSc number lSSc number dSSc number Controls number Outcomea Other findings
Lekakis et al. [40], 1998 12 0 12 12  
Cheng et al. [30], 2003 52 33 19 21  
Zakopoulos et al. [29], 2003 40 15 30 45  
Bartoli et al. [32], 2007 53 45 8 53 CIMT is higher in patients carrying D allele of ACE gene.
Bartoli et al. [38], 2007 35 11 24 20 No correlation between CIMT and cardiovascular risk factors was found.
Sherer et al. [34], 2007 44 38 6 32 CIMT is higher in patients with IgM anti-HSP-65.
Szucs et al. [28], 2007 29 19 10 29 CIMT correlates with age and disease duration.
Roustit et al. [27], 2008 42 33 9 33  
Hettema et al. [26], 2008 49 45 4 32  
Liu et al. [31], 2011 25 17 8 25  
  1. aCarotid intima-media thickness (CIMT) in patients with systemic sclerosis (SSc) relative to controls: ↑, CIMT higher in patients with SSc than controls; ↔, no difference in CIMT between patients and controls. ACE, angiotensin-converting enzyme; anti-HSP-65, anti-heat shock protein-65; D, deletion; dSSc, diffuse systemic sclerosis; lSSc, limited systemic sclerosis.