Arthritis Research & Therapy

Table 1 Studies of carotid intima-media thickness in systemic sclerosis

From: Cardiovascular disease in systemic sclerosis - an emerging association?

Reference	Total SSc number	lSSc number	dSSc number	Controls number	Outcome^a	Other findings
Lekakis et al. [40], 1998	12	0	12	12	↑
Cheng et al. [30], 2003	52	33	19	21	↔
Zakopoulos et al. [29], 2003	40	15	30	45	↔
Bartoli et al. [32], 2007	53	45	8	53	↑	CIMT is higher in patients carrying D allele of ACE gene.
Bartoli et al. [38], 2007	35	11	24	20	↑	No correlation between CIMT and cardiovascular risk factors was found.
Sherer et al. [34], 2007	44	38	6	32	↑	CIMT is higher in patients with IgM anti-HSP-65.
Szucs et al. [28], 2007	29	19	10	29	↔	CIMT correlates with age and disease duration.
Roustit et al. [27], 2008	42	33	9	33	↔
Hettema et al. [26], 2008	49	45	4	32	↔
Liu et al. [31], 2011	25	17	8	25	↔

^aCarotid intima-media thickness (CIMT) in patients with systemic sclerosis (SSc) relative to controls: ↑, CIMT higher in patients with SSc than controls; ↔, no difference in CIMT between patients and controls. ACE, angiotensin-converting enzyme; anti-HSP-65, anti-heat shock protein-65; D, deletion; dSSc, diffuse systemic sclerosis; lSSc, limited systemic sclerosis.

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