Arthritis Research & Therapy

Table 3 Studies of arterial stiffness in systemic sclerosis

From: Cardiovascular disease in systemic sclerosis - an emerging association?

Reference	Total SSc number	lSSc number	dSSc number	Controls number	Outcome^a	Other findings
Andersen et al. [44], 2002	24	20	4	24	AI ↑
Sfi kakis et al. [39], 2007	24	6	18	52	AI ↔	Four weeks of bosentan therapy had no effect on AI.
Roustit et al. [27], 2008	42	33	9	33	PWV ↔
Cypiene et al. [37], 2008	17	0	17	34	AI ↑ PWV ↑
Timar et al. [49], 2008	40	31	9	35	AI ↑ PWV ↑	PWV was higher in patients with limited disease and correlated with disease duration.
Peled et al. [50], 2009	18	-	-	13	AI ↔	No difference was found between patients with SSc with and without PAH.
Liu et al. [31], 2011	25	17	8	25	PWV ↑ at forearm and arm	PWV ↔ at upper arm, aorta, and leg

^aArterial stiffness in patients with systemic sclerosis (SSc) relative to controls: ↑, higher in patients with SSc than controls; ↔, no difference between patients with SSc and controls. AI, augmentation index; dSSc, diffuse systemic sclerosis; lSSc, limited systemic sclerosis; PAH, pulmonary arterial hypertension; PWV, pulse wave velocity.

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