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Figure 5 | Arthritis Research & Therapy

Figure 5

From: High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

Figure 5

HMGB1 in complex with IL-1α or IL-1β utilizes IL-1RI for the induction of cytokine production. Synovial fibroblasts were pre-incubated with soluble IL-1RA one to two hours prior to indicated stimulation. IL-1RA significantly inhibited the: A) HMGB1-IL-1α complex mediated IL-8 and IL-6 production compared with untreated groups, determined by CBA (pooled data from RASFs and OASFs n = 6), B) HMGB1-IL-1β mediated TNF production, compared with untreated group, determined with Elispot (pooled data from RASFs and OASFs n = 4) and C) HMGB1-IL-1β complex-mediated IL-8 and IL-6 production compared with untreated groups, determined by CBA (pooled data from RASFs and OASFs n = 9). P-values were calculated using Mann Whitney test. * (P < 0.05) ** (P < 0.01) *** (P < 0.001).

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Arthritis Research & Therapy

ISSN: 1478-6362

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