Figure 3

Afferent lymphatic drainage in the lower limb is significantly decreased after PLN collapse. NIR-ICG imaging was performed on the TNF-Tg mice described in Figure 1 to quantify lymphatic flow in the lower limb. The real time video of the NIR-ICG imaging session was used to quantify the four outcome measures of lymphatic flow from the foot to expanding (Exp) and collapsed (Col) PLN, and the data are presented as the mean +/- SD for the group (n = 3, * P < 0.05 vs. Exp).