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Table 4 Rates of myocardial infarction and stroke in the all-control population

From: Integrated safety in tocilizumab clinical trials

  All-control population
n= 4,199
  Control
n= 1,555
Tocilizumab
4 mg/kg + DMARDs
n= 774
Tocilizumab
8 mg/kg + DMARDs
n= 1,870
Rate/100 PY (95% CI), (number of events)
Myocardial infarction 0.49 (0.13, 1.24), (4) 0.18 (0.00, 0.99), (1) 0.17 (0.02, 0.61), (2)
Stroke 0.24 (0.03, 0.88), (2) 0.0 0.33 (0.09, 0.86), (4)
  1. CI, confidence interval; DMARD, disease-modifying antirheumatic drug; PY, patient-years. Multiple occurrences of the same adverse event in individual patients were counted.