The percentage of GAG loss in six days (A) and proteoglycan biosynthesis measured from days 4 to 6 in bovine cartilage in response to TNFα, DEX and glucocorticoid receptor antagonist, RU 486 (B). RU reversed the effect of DEX in sulfate incorporation. In each condition, n = 5 cartilage disks. * = P < 0.05 (only selected comparisons are shown). DEX, dexamethasone; GAG, glycosaminoglycans; RU486, a glucocorticoid receptor antagonist; TNFα, tumor necrosis factor alpha.