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Figure 8 | Arthritis Research & Therapy

Figure 8

From: Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines

Figure 8

Effects of CMK on GAG loss in treatment conditions. Percentage of GAG loss from bovine cartilage in response to treatments with TNFα, IL-6/sIL-6R, mechanical injury and CMK, a general inhibitor for PCs. CMK significantly reduced GAG loss caused by TNFα + IL-6 + mechanical injury. In each condition, n = 5 cartilage disks. *P < 0.05 (only comparisons from selected hypotheses are shown). CMK, decanoyl-RVKR-CMK, a general proprotein convertase inhibitor; GAG, glycosaminoglycans; IL-6, interleukin 6; PC, proprotein convertase; sIL-6R, soluble interleukin-6 receptor; TNFα, tumor necrosis factor alpha.

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Arthritis Research & Therapy

ISSN: 1478-6362

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