| |
DEGs, n (%)
|
|---|
|
Characteristics
|
Upregulation
|
Downregulation
|
Total
|
|---|
|
Ex vivo
| | | |
|
Inc/Nv
|
322 (100%)
|
0 (0%)
|
322
|
|
Pk/Nv
|
31 (53.4%)
|
27 (46.6%)
|
58
|
|
Rec/Nv
|
28 (80%)
|
7 (20%)
|
35
|
|
In vitro
| | | |
|
Preclinical arthritis rats
|
41 (67.2%)
|
20 (32.8%)
|
61
|
|
Preclinical Bhsp65-tolerized rats
|
579 (98%)
|
12 (2%)
|
591
|
- aDEG: differentially expressed gene. "Ex vivo" group shows DEGs in lymph node cells (LNCs) at incubation (Inc), peak (Pk) or recovery (Rec) phase compared to naïve (Nv) state; "in vitro" group shows DEGs induced by mycobacterial heat shock protein 65 (Bhsp65) compared to baseline control (LNCs cultured in medium alone). In Bhsp65-tolerized group, only 76 (12.86%) of the 579 DEGs were related to immune activity (innate immunity, cell-mediated immunity and humoral immunity). The major groups comprised genes relating to cellular proliferation 127 (21.5%) and metabolism 137 (23.2%).
