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Table 3 The comparative gene expression profiles of preclinical arthritis rats and Bhsp65-tolerized rats for the subsets of genes that play a role in the pathogenesis of arthritisa

From: The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge

   Fold change (compared to baseline)
Gene symbol Gene name Preclinical arthritis rats Bhsp65-tolerized rats
Costimulatory molecule
    Cd86 CD86 molecule # +2.06*
Cytokine or cytokine receptor
    Ifi47 Interferon γ-inducible protein 47 +2.44* +2.37*
    Ifi27l1 Interferon α-inducible protein 27-like 1 +2.14* #
    Il1a Interleukin 1α +4.61* +3.21*
    Il1b Interleukin 1β # +3.05*
    Lta Lymphotoxin α (TNF superfamily, member 1) # +2.10*
    Socs1 Suppressor of cytokine signaling 1 +3.67* +3.14*
    Socs3 Suppressor of cytokine signaling 3 # +2.44*
    Ifng Interferon γ +10.00* +9.09*
    Il12rb2 Interleukin 12 receptor β2 +4.08* +3.89*
    Il10 Interleukin 10 # +2.07*
    Il33 Interleukin 33 -2.50* #
    LOC301289 Similar to interleukin 17 precursor (IL-17) +16.74* #
    Il17f Interleukin 17F +7.86* #
    RGD1561292 Interleukin 22 +7.26* #
Chemokine/receptor
    Cxcl10 Chemokine (C-X-C motif) ligand 10 +8.02* +8.15*
    Ccr5 Chemokine (C-C motif) receptor 5 +2.22* +2.50*
    Cxcr7 Chemokine (C-X-C motif) receptor 7 -2.47* #
Angiogenesis    
    Wars Tryptophanyl RNA synthetase +2.29* +2.17*
    Vegfa Vascular endothelial growth factor A # +2.21*
    Nos2 Nitric oxide synthase 2, inducible +7.83* +4.77*
Others    
    Bst2 Bone marrow stromal cell antigen 2 +2.90* +3.04*
    Slc7a2 Solute carrier family 7 (cationic amino acid transport) +4.98* +4.15*
  1. aBhsp65: mycobacterial heat shock protein 65. The genes listed were selected using false discovery rate < 5% and ≥2-fold change as the cutoff; +, upregulation; -, downregulation (- number); *significant compared to the corresponding baseline expression; #not significant compared to the corresponding baseline expression.