Figure 1

Dose-response effect of low concentrations of CNP. Chondrocyte/agarose constructs were cultured under free-swelling conditions with 0.1 to 100 pM CNP and 0 or 10 ng/nl IL-1β and/or 5 μM KT5823 for 48 hours. (a) NO release; (b) prostaglandin E₂ (PGE₂) release; (c) [³H]-thymidine; and (d) ³⁵SO₄ incorporation (n = 6). (δ), significant comparisons for untreated versus CNP; (*), significant comparisons for IL-1β versus IL-1β + CNP; (+), significant comparisons for untreated versus IL-1β + CNP; (ψ), significant comparisons for IL-1β versus IL-1β + CNP + KT5823.