Effect of CNP and dynamic compression on gene expression. Chondrocyte/agarose constructs were cultured with 0 or 10 ng/nl IL-1β and either 100 pM CNP or 100 nM CNP and/or 5 μM KT5823 for 6 and 48 hours (n = 8). (a) iNOS, (b) COX-2, (c) aggrecan, and (d) collagen type II. (*), significant comparisons in unstrained and strained constructs for the multiple treatment conditions as shown. All other comparisons (not indicated) were not significant.