Figure 3

Binding immunoglobulin protein attenuates inflammation in synovial membrane transplants via IL-10. Equal sized pieces of rheumatoid arthritis synovial membrane (RASM) were transplanted into severe combined immunodeficient mice. After successful engraftment, binding immunoglobulin protein (BiP) (10 μg/animal) or human serum albumin (HSA) (10 μg/animal) were administered intravenously concomitantly with either a neutralising anti-IL-10 antibody (aIL-10) or isotype control antibody. The RASM graft was removed after 12 days and weighed as a surrogate measure of inflammation. The results of four animals in each group are shown.