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Table 1 Surface integrin levels of the predominant cell types in the rheumatoid arthritis synovium

From: Integrins and their ligands in rheumatoid arthritis

  α1 α2 α3 α4 α5 α6 αν β1 β2 β3 β5
Synovial fibroblast ++ - +(+) - +++ + +++ +++ - ++ ?
Macrophage + + + +++ +++ (+) +++ +++ ++ +++ +
Endothelium ++ + ++ + +++ + +++ +++ - +++ +
T lymphocyte (Th1) ++ + ++ +++ +++ + +++ +++ ++ +++ +
Th17 cell - ++ ++ ++ +++ + +++ +++ ++ ? ?
B lymphocyte ++ + ++ +++ +++ + ++ +++ ++ ? ?
  1. For most integrins, expression level data in the literature are given as 'high' or 'strong'. This makes it hard to estimate integrin levels on different cell populations. We consulted several publications and, albeit subjectively, categorized integrin expression levels on a range from strong to weak expression (indicated by one, two, or three plus signs). ?, There is no available data in the literature about the expression of respective integrins.