Skip to main content

Table 1 Expression of IL-17 by mast cells, T cells and macrophages in synovial tissue

From: RETRACTED ARTICLE: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium

Demographics ACPA+ RA (n= 34) ACPA- RA (n= 25) OA (n= 29) Pvalue
Age (years) 55 (32 to 80) 63 (19 to 80) 67 (42 to 83)  
Gender (females/males) 22/12 14/11 21/8  
Disease duration (years) 7 (0 to 28) 8 (0 to 24) Unknown  
Median IL-17+ cells 21 (0 to 118) 12 (1 to 61) 17 (0 to 50) 0.381
IL-17+ mast cells (%) 97 (40 to 100) 96 (0 to 100) 93 (0 to 100) 0.969
IL-17+ T cells (%) 0 (0 to 100) 0 (0 to 24) 2 (0 to 49) 0.558
IL-17+ MØ (%) 0 (0 to 78) 4 (0 to 100) 1 (0 to 58) 0.382
Median MCs 28 (0 to 123) 19 (0 to 92) 25 (0 to 76) 0.198
MCs (CD117+) expressing IL-17 (%) 91 (13 to 100) 83 (0 to 100) 96 (4 to 100) 0.599
T cells (CD3+), n 21 (0 to 592) 10 (0 to 115) 11 (0 to 265) 0.609
T cells (CD3+) expressing IL-17 (%) 0 (0 to 60) 0 (0 to 66) 1 (0 to 78) 0.149
MØ (CD68+), n 71 (1 to 390) 53 (1 to 302) 66 (2 to 231) 0.634
MØ (CD68+) expressing IL-17 (%) 0 (0 to 16) 0 (0 to 14) 0 (0 to 11) 0.689
  1. ACPA: anticitrullinated protein antibody; MC: mast cell; MØ: macrophage; OA: osteoarthritis; RA: rheumatoid arthritis. Results are expressed as medians (minimum-maximum). Mast cells are defined as CD117+ cells, T cells are defined as CD3+ cells and macrophages are defined as CD68+ cells.