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Table 3 Comparison of effectiveness algorithm versus effectiveness gold standard for biologic users

From: Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis

  Effectiveness gold standard*    
Met effectiveness algorithm** Yes No Total PPV (95% CI) NPV (95% CI)
Yes 42 14 56 (28%) 75% (62 to 86)  
No 14 127 141 (72%)   90% (84 to 94)
Total 56 (28%) 141 (72%) 197 (100%)   
  Se 75%
(95% CI = 62 to 86)
Sp 90%
(95% CI = 84 to 94)
   
  1. CI: confidence interval; NPV: negative predictive value; PPV: positive predictive value; Se: sensitivity; Sp: specificity. *DAS28 ≤ 3.2 or DAS28 improvement by > 1.2 units and high adherence (for example, ≥ 80%) to the biologic started on the index date. **The components of the effectiveness algorithm are shown in Table 1.