Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis

Table 3 Comparison of effectiveness algorithm versus effectiveness gold standard for biologic users

	Effectiveness gold standard*
Met effectiveness algorithm**	Yes	No	Total	PPV (95% CI)	NPV (95% CI)
Yes	42	14	56 (28%)	75% (62 to 86)
No	14	127	141 (72%)		90% (84 to 94)
Total	56 (28%)	141 (72%)	197 (100%)
	Se 75% (95% CI = 62 to 86)	Sp 90% (95% CI = 84 to 94)

CI: confidence interval; NPV: negative predictive value; PPV: positive predictive value; Se: sensitivity; Sp: specificity. *DAS28 ≤ 3.2 or DAS28 improvement by > 1.2 units and high adherence (for example, ≥ 80%) to the biologic started on the index date. **The components of the effectiveness algorithm are shown in Table 1.

ISSN: 1478-6362