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Table 1 Characteristics of 196 patients with recent onset IP and in those with and without IR

From: Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study

Variable at baseline All pts
n= 196
IR
(HOMA IR ≥ 2.29)
n= 118 (60%)
No IR
HOMA IR < 2.29
n= 78 (40%)
P-value
Age when first seen (years) 49 (40 to 57) 49 (41 to 56) 48 (37 to 57) 0.49
Male gender 59 (30%) 38 (32%) 21 (27%) 0.43
Current smoker 50 (26%) 27 (23%) 23 (29%) 0.30
Obese (BMI ≥ 30) 57 (30%) 46 (40%) 11 (15%) < 0.001
On treatment for or diagnosed with DM 26 (13%) 16 (14%) 10 (13%) 0.88
Fasting blood glucose (mmol/L) * 4.7 (4.4 to 5.0) 4.8 (4.5 to 5.1) 4.5 (4.3 to 4.8) < 0.001
Fasting insulin (μU) 12.7 (8.9 to 18.1) 16.7 (13.2 to 21.6) 8.2 (6.0 to 9.4) < 0.001
HOMA-IR 2.7 (1.8 to 3.9) 3.5 (2.8 to 4.8) 1.6 (1.2 to 1.9) < 0.001
SBP (mmHg) * 132 (17) 135 (17) 129 (15) 0.04
DBP (mmHg) * 81 (10) 83 (10) 79 (9) 0.01
On treatment for hypertension 19 (10%) 13 (11%) 6 (8%) 0.44
TG (mmol/L) * 1.4 (0.6) 1.6 (0.6) 1.1 (0.5) < 0.001
T.Chol (mmol/L) * 5.4 (1.1) 5.5 (1.1) 5.2 (1.1) 0.24
HDL (mmol/L) * 1.5 (0.4) 1.5 (0.5) 1.6 (0.4) 0.03
LDL (mmol/L) * 3.2 (0.9) 3.3 (0.9) 3.1 (0.9) 0.43
On statin treatment 11 (6%) 5 (4%) 6 (8%) 0.30
IP symptom duration (months) 6.7 (4.6 to 10.7) 6.5 (4.5 to 9.9) 7.0 (4.7 to 11.8) 0.28
Age at IP symptom onset 48 (40 to 56) 48 (40 to 55) 48 (36 to 57) 0.42
RF positive 90 (47%) 63 (55%) 27 (35%) 0.01
ACPA positive 66 (34%) 50 (44%) 16 (21%) < 0.001
Fulfil ACR criteria for RA 87 (44%) 58 (49%) 29 (37%) 0.10
Swollen joint count (/51) 4 (1 to 7) 4 (2 to 9) 4 (1 to 7) 0.44
Tender joint count (/51) 8 (2 to 18) 8 (2 to 18) 9 (3 to 17) 0.87
Both swollen & tender (/51) 2 (0 to 6) 2 (0 to 6) 2 (0 to 5) 0.96
CRP (mg/L) 10 (7 to 17) 11 (5 to 21) 9 (7 to 13) 0.21
DAS28CRP 3.9 (3.0 to 4.8) 3.9 (3.0 to 4.9) 3.9 (3.1 to 4.7) 0.73
HAQ 0.88 (0.38 to 1.38) 0.88 (0.38 to 1.68) 0.88 (0.38 to 1.38) 0.26
On steroids
prior to baseline assessment
43 (22%) 24 (20%) 19 (24%) 0.51
On DMARDs
prior to baseline assessment
105 (54%) 67 (57%) 38 (49%) 0.27
On MTX prior to baseline assessment 60 (31%) 36 (31%) 24 (31%) 0.97
On HCQ prior to baseline assessment 11 (6%) 6 (5%) 5 (6%) 0.69
  1. All data are presented as n (%) except where we indicate that either median (IQR) or mean (SD) * were used.
  2. ACPA, anti-CCP antibody; ACR, American College of Rheumatology; CRP, C-reactive protein; DAS 28CRP , Disease Activity Score calculated using CRP; DBP, diastolic blood pressure; DM, diabetes mellitus; HAQ, Health Assessment Questionnaire; HCQ, hydroxychloroquine; HDL, high density lipoprotein; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; IP, inflammatory polyarthritis; LDL, low density lipoprotein; MTX, methotrexate; RF, rheumatoid factor; SBP, systolic blood pressure;
  3. T.chol, total cholesterol; TG, triglycerides