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Table 3 Associations between rheumatoid factor and anti-CCP antibodies with insulin resistance alone and in combination with one another after serial adjustment

From: Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register (NOAR): an observational study

Variable Numbers of patients Association with HOMA-IR
TRF & IP risk factor adjusted IR
β-Coefficient OR (95% CI) #
RF +ve * 90 (47%) 0.867 (0.204, 1.530)
ACPA +ve * 66 (35%) 1.423 (0.701, 2.146)
RF-ve/ACPA -ve 96 (49%) 0
RF +ve/
ACPA -ve
29 (15%) -0.015 (-0.973, 0.944)
ACPA+ve/
RF -ve
6 (3%) 0.932 (-0.898, 2.763)
Both RF+ve/ACPA+ve 60 (31%) 1.472 (0.695, 2.250)
  1. * = Seropositive vs. seronegative for RF and ACPA (n = 193 and 191, respectively)
  2. † = Patients stratified into four groups depending on autoantibody status and compared with other groups (n = 191)
  3. √ = Model significantly different in patients positive for both RF and ACPA relative to those RF positive only (P = 0.0061) with age and gender and other parameters adjusted.)
  4. Linear regression producing β-coefficients were used for continuous outcome. β-coefficients are considered statistically significant if their 95% CI values do not include zero.
  5. #Logistic regression producing odds ratios used for binary outcomes. Odds ratios are considered significant if the 95% CI values do not include 1.
  6. ACPA, anti-CCP antibody; IP, inflammatory polyarthritis; RF, rheumatoid factor.