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Table 3 Human leucocyte antigen-DRB1 rheumatoid arthritis-associated alleles, odds ratios and confidence intervals in the rheumatoid arthritis patient cohort

From: HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients

Risk allele RA patients, n(%) (n= 143) Controls*, n(%) (n= 1,104) OR (95% CI) Pvalue
HLA-DRB1*01 26 (18.2) 93 (8.4) 2.4 (1.5 to 3.9) 0.0007
HLA-DRB1*04 61 (42.7) 41 (3.7) 19.3 (12.2 to 30.4) <0.0001
HLA-DRB1*10 10 (7.0) 36 (3.3) 2.2 (1.0 to 4.6) 0.0338
  1. HLA = human leucocyte antigen; OR = odds ratio; RA = rheumatoid arthritis. *Data from Robinson and colleagues [31, 32].