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Table 3 Human leucocyte antigen-DRB1 rheumatoid arthritis-associated alleles, odds ratios and confidence intervals in the rheumatoid arthritis patient cohort

From: HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients

Risk allele

RA patients, n(%) (n= 143)

Controls*, n(%) (n= 1,104)

OR (95% CI)

Pvalue

HLA-DRB1*01

26 (18.2)

93 (8.4)

2.4 (1.5 to 3.9)

0.0007

HLA-DRB1*04

61 (42.7)

41 (3.7)

19.3 (12.2 to 30.4)

<0.0001

HLA-DRB1*10

10 (7.0)

36 (3.3)

2.2 (1.0 to 4.6)

0.0338

  1. HLA = human leucocyte antigen; OR = odds ratio; RA = rheumatoid arthritis. *Data from Robinson and colleagues [31, 32].
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Arthritis Research & Therapy

ISSN: 1478-6362

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