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Table 6 Association between anticyclic citrullinated peptide antibody and rheumatoid factor with shared epitope alleles according to the du Montcel classification

From: HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients

  aCCP RF
Allele OR (95% CI) Pvalue OR (95% CI) Pvalue
S1 allele (n = 55) 2.9 (0.7 to 12.4) 0.2054 4.5 (1.2 to 16.9) *0.0291
S2 allele (n = 28) 12.0 (2.4 to 59.5) 0.0019** 8.3 (1.6 to 43.3) *0.0122
S3D allele (n = 38) 7.5 (1.8 to 31.4) 0.0100* 5.3 (1.3 to 22.7) *0.0246
S3P allele (n = 61) 13.3 (3.2 to 54.4) 0.0003*** 4.5 (1.2 to 16.8) *0.0264
X allele (n = 64) 4.7 (1.2 to 17.6) 0.0213* 2.7 (0.8 to 9.8) 0.1678
  1. aCCP = anticyclic citrullinated peptide antibodies; RF = rheumatoid factor. du Montcel classification is from du Montcel et al. [7]. OR (95% CI) and P values were calculated using Fisher's exact test to compare with SE noncarrier rheumatoid arthritis patients (n = 12). *P < 0.05. **P ≤ 0.001 and ***P ≤ 0.0003 values are highly significant.