A combination of low-dose etanercept and RB200 results in normalisation of joint architecture in collagen-induced arthritis. To assess damage to cartilage and joints, we stained serial sections of hind feet (4 μm) with (a) haematoxylin and eosin or (b) toluidine blue. Tibiotarsal joint sections from animals representing the median score for each group are shown. Bars = 100 μm. (c) Percentage of sections exhibiting normal appearance (score 0), minimal synovitis and bone erosion (score 1), extensive synovial hyperplasia and some destruction of cartilage and bone (score 2), and complete destruction of the joint architecture (score 3). Data are derived from 9 to 14 sections per group.