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Table 2 The prevalence of antibody to HCMVpp65 sub-fragments in patients with autoimmunity and healthy controls

From: Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice

Ā 

Antigens

SLE

SSc

SS

RA

Normal

Age (years)

Ā 

11 to 77

48 to 79

14 to 79

21 to 81

31 to 73

Mean (years)

Ā 

33.8

61.9

53.4

54.6

63.2

Total specimen

Ā 

61

20

13

50

45

Female (%)

Ā 

93.4

95

92.3

80

57.8

Responsiveness

pp651 to 167 (%)

4/61 (7)

3/20 (15)

5/13 (38)

0/50 (0)

6/45 (13)

Ā 

pp65167 to 336 (%)

12/61 (20)

5/20 (25)

3/13 (23)

16/50 (32)

9/45 (20)

Ā 

pp65336 to 561 (%)

37/61 (61)

4/20 (20)

2/13 (15)

7/50 (14)

2/45 (4)

Ā 

pp65336 to 379 (%)

0/30 (0)

Ā Ā Ā Ā 
Ā 

pp65379 to 455 (%)

22/30 (73)

Ā Ā Ā Ā 
Ā 

pp65455 to 561 (%)

3/30 (10)

Ā Ā Ā Ā 
Ā 

pp65336 to 448 (%)

17/22 (77)

Ā Ā Ā Ā 
Ā 

pp65336 to 439 (%)

16/22 (73)

Ā Ā Ā Ā 
Ā 

pp65336 to 422 (%)

9/22 (41)

Ā Ā Ā Ā 
  1. RA, rheumatoid arthritis; SS, Sjƶgren's syndrome; SSc, systemic sclerosis. For immunoblot and ELISA assay, detection of anti-pp65 sub-fragments antibody was tested with purified human cytomegalovirus (HCMV) virions, as described in materials and methods. The HCMV positivity is defined by mean + 3 s.e.m of normal control. The results are representative of triplicated experiments.