Skip to main content

Table 1 Altered gene expression in the sensory neurons in dorsal root ganglions in a neuropathic animal model compared to the traumatic disk injury-initiated chronic discogenic pain model

From: The rat intervertebral disk degeneration pain model: relationships between biological and structural alterations and pain

Tissues Pain modulator Neuropathic pain (sciatic nerve ligation)a, reference Disk degeneration back pain modelb, relative fold induction (n= 12) (P values)
Dorsal horn Dynorphin Upregulated [28] 1.941 ± 0.162 (P < 0.05)
  NK-1 Upregulated [29] 2.512 ± 0.521 (P < 0.05)
DRG BDNF Upregulated [23] 1.841 ± 0.312 (P < 0.05)
  NPY Upregulated [24] 5.367 ± 0.474 (P < 0.05)
  CGRP Downregulated [21] 0.487 ± 0.433 (P < 0.05)
  Substance P Downregulated [22] 0.712 ± 0.251 (P < 0.05)
  Galanin Upregulated [25] 1.1 ± 0.219 (equal)
  1. BDNF = brain-derived neurotrophic factor; CGRP = calcitonin gene-related peptide; DRG = dorsal root ganglion; NK-1 = neurokinin 1; NPY = neuropeptide Y. aUpregulated and downregulated expression patterns are relative to sham controls. b25-gauge drilling was performed in 12 mice; data are means ± SEM.