IL-17A and IL-22 production correlates with CCR6+CCR10- expression in SSc CD4+ T cells. A. Frequency of CD4+CD45RA- T cells expressing CXCR3, CCR6, CCR4 or CCR10 in SSc and in HD detected by a six-color flow cytometry. Columns represent mean ± SD. B. Correlation between the percentages of IL-17+ CD4+ T cells or IL-22+ CD4+ T cells with CCR6+CCR10- in CD4+CD45RA- T cells. Full and empty dots represent SSc and HD, respectively. Continuous and dotted regression lines correspond to SSc and HD, respectively. Pearson correlation was used for statistical analysis.