Change in fatigue over time. Errorbars showing 95% confidence intervals for the change in four different fatigue measures over time. N = 122 for FSS, otherwise 121. The vertical line (zero) represents fatigue measures at baseline. FSS and FACIT-F data were normalised to a 0 to 100 scale, corresponding to fatigue VAS and vitality data. Mean change values (and standard deviations) without normalising were: FSS, 0.15 (0.12); fatigue VAS, -1.62 (2.20); FACIT-F, 0.78 (0.76); and vitality, -3.00 (1.48). Vitality (low values representing high fatigue) showed a statistically but not clinically significant decrease over time. The tendencies in the other measures were increasing fatigue by FSS and decreasing fatigue by VAS and FACIT-F. See Table 1 legend for definitions.