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Table 2 Prevalence of autoantibodies in 863 scleroderma patients

From: Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features

Autoantibodies

Patients, n(%)

Positive for antinuclear antibodies

813 (94.2)

Antibodies highly associated with SSc or scleroderma overlap syndromes

704 (81.6)

   Anti-centromere

310 (35.9)

   Anti-topoisomerase I

260 (30.1)

   Anti-PM-Scl

42 (4.9)

   Anti-U1-RNP

41 (4.8)

   Anti-RNA polymerase

33 (3.8)

   Anti-fibrillarin

12 (1.4)

   Anti-To

2 (0.2)

   Anti-Ku

10 (1.2)

   Anti-Jo-1/-Pl-7/-OJ

4 (0.5)

   Anti-U11-RNP

1 (0.1)

Other autoantibodies

 

   Anti-Ro and/or anti-La

206 (23.9)

Anti-Ro52

187 (21.7)

Anti-Ro60

59 (6.8)

Anti-La

16 (1.9)

   Anti-mitochondrial M2

41 (4.8)

   Anti-p25/p23

28 (3.2)

   Anti-NOR-90

6 (0.7)

   Anti-SL

9 (1.0)

   Anti-Sm

4 (0.5)

   Anti-Sp100

4 (0.5)

   Other (known or unknown)

363 (42.1)

Negative for all highly SSc-associated antibodies

159 (18.4)

Negative for antinuclear antibodies

50 (5.8)

Autoantibody-negative by all criteria used

38 (4.4)

  1. ANA = antinuclear antibodies; SSc = systemic sclerosis.