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Table 5 Correlations of clinical features with SSc associated autoantibodies

From: Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma: correlation with characteristic clinical features

  ACA
(310)
ATA
(260)
Anti-PM-Scl
(42)
Anti-U1-RNP
(41)
Anti-RNA -P
(33)
Anti-Fibrillarin
(12)
Anti-Ku
(10)
Anti-Ro52
(187)
Anti-Ro60
(59)
Anti-La
(16)
AMA
(41)
Anti-p25/23
(28)
ANA-negative
(50)
no SSc associated ab's
(161)
male sex
148 (17.1%)
17
0.19 (0.11 to 0.32)
P < 0.0001
64
2.02 (1.4 to 2.91)
p = 0.0002
6 9 8 4 2 23
0.62 (0.38 to 0.997
p = 0.049
12 2 1 1 10 41
1.90 (1.261 to 2.863)
p = 0,0035
age at disease onset < 50 y
399/781 (51.1%)
115
0.57 (0.43 to 0.77)
p = 0.0003
135
1.39 (1.02 to 1.88)
p = 0.0431
22 29
2.92 (1.40 to 6.07)
p = 0.0029
13 8 4 77 31 10 20 8 18 73
Rodnan skin score > 10
294/750 (39.2%)
58
0.27 (0.19 to 0.38)
P < 0.0001
132
3.10 (2.24 to 4.27)
P < 0.0001
14 9 18
3.24 (1.44 to 7.31)
p = 0.0042
7 1 58 23 6 10 11 14 56
Raynaud's phenomenon
819 (94.9%)
301
2.26 (1.07 to 4.77)
p = 0.0349
252 37 41 32 12 10 184
3.96 (1.2 to 12.94
p = 0.0133
58 16 41 28 43
0.29 (0.12 to 0.70)
p = 0.0104
140
0.23 (0.12 to 0.42)
P < 0.0001
Digital ulcers
216/840 (25.7%)
55
0.50 (0.36 to 0.71)
P < 0.0001
106
3.18 (2.30 to 4.41)
P < 0.0001
9 11 7 4 1 48 19 6 13 6 4
0.26 (0.09 to 0.76)
p = 0.0076
28
0.60 (0.39 to 0.94)
p = 0.024
Pulmonary hypertension
126 (14.6%)
57
1.58 (1.08 to 2.32)
p = 0.0208
36 2 9 4 1 0 31 14 2 2 7 2
0.23 (0.06 to 0.97)
p = 0.0232
17
Pulmonary fibrosis
287 (33.3%)
39
0.18 (0.12 to 0.26)
P < 0.0001
151
4.76 (3.48 to 6.50)
P < 0.0001
16 11 7 2 6 69 30
2.20 (1.29 to 3.75
p = 0.0040
9 6
0.33 (0.14 to 0.79)
p = 0.01
4
0.33 (0.11 to 0.95)
p = 0.0393
11 55
Lung restrictive defect
218/833 (26.2%)
41
0.31 (0.21 to 0.45)
P < 0.0001
104
2.96 (2.14 to 4.09)
P < 0.0001
9 7 8 3 4 45 19 4 8 4 10 34
Esophageal involvement
535 (62.0%)
198 175
1.39 (1.02 to 1.89)
p = 0.039
14
0.29 (0.152 to 0.56)
p = 0.0001
29 20 7 6 120 39 13 24 21 27 87
0.67 (0.47 to 0.94)
p = 0.0243
Proteinuria
90/830 (10.8%)
23
0.56 (0.34 to 0.92)
p = 0.0207
34 4 4 4 1 1 15 9 2 3 1 5 19
Cardiac involvement
114 (13.2%)
27
0.51 (0.32 to 0.81)
p = 0.0033
45
1.62 (1.08 to 2.44)
p = 0.0216
5 7 5 1 2 20 9 1 4 1 5 22
Musculoskeletal involvement
421/852 (49.4%)
131
0.64 (0.48 to 0.85)
p = 0.0022
130 20 28
2.49 (1.25 to 4.96)
p = 0.009
17 10
5.22 (1.14 to 23.97)
p = 0.0202
6 80
0.71 (0.51 to 0.99)
p = 0.0468
32 12
3.13 (1.002 to 9.79)
p = 0.0447
17 9 25 79
Synovitis
157/837 (18.8%)
35
0.43 (0.29 to 0.65)
P < 0.0001
62
1.71 (1.19 to 2.45)
p = 0.0049
8 13
2.27 (1.14 to 4.53)
p = 0.0326
8 2 2 32 15 5 2
0.21 (0.05 to 0.89)
p = 0.0216
2 10 29
Joint contractures
253/840 (30.1%)
54
0.36 (0.25 to 0.50)
P < 0.0001
107
2.26 (1.65 to 3.08)
P < 0.0001
9 9 10 6 2 49 23 6 9 9 20
1.93 (1.05 to 3.54)
p = 0.0436
56
Tendon friction rubs
88/840 (10.5%)
14
0.30 (0.16 to 0.53)
P < 0.0001
32 2 5 6 3 1 21 5 2 2 0 6 25
1.95 (1.18 to 3.22)
p = 0.0122
CK elevation
74/835 (8.9%)
14
0.37 (0.21 to 0.68)
p = 0.0009
20 19
3.56 (1.67 to 7.57)
p = 0.0023
5 6
2.60 (1.03 to 6.55)
p = 0.0485
0 3
5.32 (1.30 to 21.72)
p = 0.038
21 8 2 1 0 6 16
Sicca syndrome
366/858 (42.7%)
150
1.44 (1.19 to 6.61)
p = 0.0119
98 14 18 12 5 4 96
1.57 (1.13 to 2.17)
p = 0.0075
33
1.85 (1.08 to 3.17)
p = 0.0275
12
4.14 (1.32 to 12.93)
p = 0.0102
19 20
3.50 (1.52 to 8.03)
p = 0.0029
23 66
Mouth involvement
223/829 (26.9%)
64
0.61 (0.44 to 0.85)
p = 0.0034
93
2.1 (1.53 to 2.93)
P < 0.0001
10 7 10 3 4 49 18 6 11 6 12 34
ESR > 25 mm/h
199/741 (26.9%)
58
0.70 (0.49 to 0.99)
p = 0.046
75
1.55 (1.10 to 2.19)
p = 0.015
4
0.33 (0.11 to 0.94)
p = 0.0325
14 5 0 0 60
1.76 (1.21 to 2.54)
p = 0.0039
28
3.39 (1.92 to 5.97)
P < 0.0001
9
3.62 (1.33 to 9.86)
p = 0.0447
10 5 15 42
  1. ACA, anti-centromere antibodies; AMA, antimitochondrial antibodies; ANA, antinuclear antibodies; ATA, anti-topoisomerase I antibodies; CK, creatine kinase; ESR, erythrocyte sedimentation rate; RNAP = RNA polymerase; RNP = ribonucleoprotein; SSc, systemic sclerosis. Dichotomous variables are expressed as raw numbers, OR (95% CI) and P values.