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Table 1 Summary of significant differences detected (P < 0.05) among MZ twins discordant for SAID and unrelated, matched controls*

From: Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases*

Affected vs. unaffected twins      
Up-Regulated: Accession No. P-value Exp. Ratio Location Function
α-1-antichymotrypsin precursor P01011 0.0008 1.37 Extracellular Protease inhibitor
Syntaxin 17 P56962 0.0022 1.30 Plasma membrane Vesicular transport
Keratin type II P35908 0.0040 1.26 Cytoplasm Structural
Complement C8 precursor P07358 0.0070 1.14 Extracellular Immune response
α-1-acid glycoprotein P02763 0.0073 1.42 Extracellular Acute phase reaction
Retinoblastoma-binding protein 1 P29374 0.0117 1.53 Nucleus Transcriptional regulation
Complement C4 precursor P01028 0.0122 1.36 Extracellular Immune response
Plasma protease C1 inhibitor precursor P05155 0.0144 1.19 Extracellular Protease inhibitor
Maltase-glucoamylase intestinal O43451 0.0167 1.51 Cytoplasm Carbohydrate catabolism
Hematopoietic-specific transmembrane-4 protein Q96HJ5 0.0197 1.21 Plasma membrane Immune response
Ubiquitin carboxyl-terminal hydrolase 29 Q9HBJ7 0.0271 1.44 Unknown Peptidase
Complement C6 precursor P13671 0.0282 1.19 Extracellular Immune response
Complement C9 precursor P02748 0.0390 1.18 Extracellular Immune response
Kallikrein precursor P03952 0.0407 1.22 Extracellular Peptidase
Myomesin 1 P52179 0.0418 1.27 Myofibers Structural
Leucine-rich α-2-glycoprotein precursor P02750 0.0473 1.26 Extracellular pleiotropic**
Down-Regulated:      
Serum paraoxonase/arylesterase 1 P27169 0.0195 0.82 Extracellular Detoxification/anti-oxidation
Apolipoprotein A-II precursor P02652 0.0231 0.75 Extracellular Transporter
Fetuin-A P02765 0.0278 0.79 Extracellular Protease inhibitor
Minor histocompatibility antigen H13 Q8TCT9 0.0356 0.78 Endoplasmic reticulum Protease
Affected Twins vs. Unrelated, Matched Controls      
Up-Regulated:      
Leucine-rich α-2-glycoprotein precursor P02750 0.0086 1.46 Extracellular pleiotropic**
Fibrinogen β-precursor P02675 0.0109 1.33 Extracellular Coagulation
Apolipoprotein C-IV precursor P55056 0.0155 1.69 Extracellular Transporter
Apolipoprotein E precursor P02649 0.0193 1.24 Extracellular Transporter
α-1-microglobulin/Inter-α-trypsin inhibitor P02760 0.0199 1.41 Extracellular Protease inhibitor
Nuclear receptor co-activator 6 Q14686 0.0307 1.33 Nucleus Transcriptional regulation
Plasma retinol-binding protein precursor P02753 0.0356 1.30 Extracellular Transporter
Retinoblastoma-binding protein 1 P29374 0.0361 1.43 Nucleus Transcriptional regulation
Apolipoprotein C-III precursor P02656 0.0395 1.29 Extracellular Transporter
Kallistatin precursor P29622 0.0461 1.19 Extracellular Peptidase inhibitor
Down-Regulated:      
Coagulation factor XII precursor P00748 0.0017 0.76 Extracellular Coagulation
Peroxisomal carnitine octanoyl transferase Q9UKG9 0.0196 0.67 Peroxisome Metabolism fatty acid
Ficolin 3 precursor NP_003656 0.0218 0.83 Extracellular Immune response
Fibrinogen C NP_116232 0.0248 0.83 Extracellular Coagulation
Probable ATP-dependent helicase DHX37 Q8IY37 0.0253 0.89 Nucleus RNA helicase
Polycystin 1 precursor P98161 0.0341 0.78 Plasma membrane Transporter/Signaling
Complement C1q A chain precursor P02745 0.0350 0.69 Extracellular Immune response
NK cell receptor 3DL1 precursor P43629 0.0368 0.85 Plasma membrane Immune response
Serum paraoxonase/arylesterase 1 P27169 0.0381 0.75 Extracellular Detoxification/anti-oxidation
Unaffected Twins vs. Unrelated, Matched Controls      
Up-Regulated:      
Apolipoprotein C-IV precursor P55056 0.0436 1.38 Extracellular Transporter
Apolipoprotein C-III precursor P02656 0.0493 1.24 Extracellular Transporter
Histone deacetylase 3 O15379 0.0494 1.12 Nucleus Chromatin modulation
Down-Regulated:      
Alpha-1-antichymotrypsin precursor P01011 0.0036 0.84 Extracellular Protease inhibitor
Fibrinogen C NP_116232 0.0046 0.78 Extracellular Coagulation
Ficolin 3 precursor NP_003656 0.0049 0.80 Extracellular Immune response
Keratin type II P35908 0.0232 0.87 Cytoplasm Structural
Syntaxin 17 P56962 0.0311 0.85 Plasma membrane Vesicular transport
Serum paraoxonase/arylesterase 1 P27169 0.0466 0.69 Extracellular Detoxification/anti-oxidation
  1. *Abbreviations: No., number; Exp., expression
  2. **protein-protein interaction; cell adhesion; signal transduction; granulocyte differentiation