Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases*

O'Hanlon, Terrance P; Li, Zhuoyan; Gan, Lu; Gourley, Mark F; Rider, Lisa G; Miller, Frederick W

doi:10.1186/ar3506

Table 1 Summary of significant differences detected (P < 0.05) among MZ twins discordant for SAID and unrelated, matched controls*

From: Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases*

Affected vs. unaffected twins
Up-Regulated:	Accession No.	P-value	Exp. Ratio	Location	Function
α-1-antichymotrypsin precursor	P01011	0.0008	1.37	Extracellular	Protease inhibitor
Syntaxin 17	P56962	0.0022	1.30	Plasma membrane	Vesicular transport
Keratin type II	P35908	0.0040	1.26	Cytoplasm	Structural
Complement C8 precursor	P07358	0.0070	1.14	Extracellular	Immune response
α-1-acid glycoprotein	P02763	0.0073	1.42	Extracellular	Acute phase reaction
Retinoblastoma-binding protein 1	P29374	0.0117	1.53	Nucleus	Transcriptional regulation
Complement C4 precursor	P01028	0.0122	1.36	Extracellular	Immune response
Plasma protease C1 inhibitor precursor	P05155	0.0144	1.19	Extracellular	Protease inhibitor
Maltase-glucoamylase intestinal	O43451	0.0167	1.51	Cytoplasm	Carbohydrate catabolism
Hematopoietic-specific transmembrane-4 protein	Q96HJ5	0.0197	1.21	Plasma membrane	Immune response
Ubiquitin carboxyl-terminal hydrolase 29	Q9HBJ7	0.0271	1.44	Unknown	Peptidase
Complement C6 precursor	P13671	0.0282	1.19	Extracellular	Immune response
Complement C9 precursor	P02748	0.0390	1.18	Extracellular	Immune response
Kallikrein precursor	P03952	0.0407	1.22	Extracellular	Peptidase
Myomesin 1	P52179	0.0418	1.27	Myofibers	Structural
Leucine-rich α-2-glycoprotein precursor	P02750	0.0473	1.26	Extracellular	pleiotropic**
*Down-Regulated:*
Serum paraoxonase/arylesterase 1	P27169	0.0195	0.82	Extracellular	Detoxification/anti-oxidation
Apolipoprotein A-II precursor	P02652	0.0231	0.75	Extracellular	Transporter
Fetuin-A	P02765	0.0278	0.79	Extracellular	Protease inhibitor
Minor histocompatibility antigen H13	Q8TCT9	0.0356	0.78	Endoplasmic reticulum	Protease
Affected Twins vs. Unrelated, Matched Controls
Up-Regulated:
Leucine-rich α-2-glycoprotein precursor	P02750	0.0086	1.46	Extracellular	pleiotropic**
Fibrinogen β-precursor	P02675	0.0109	1.33	Extracellular	Coagulation
Apolipoprotein C-IV precursor	P55056	0.0155	1.69	Extracellular	Transporter
Apolipoprotein E precursor	P02649	0.0193	1.24	Extracellular	Transporter
α-1-microglobulin/Inter-α-trypsin inhibitor	P02760	0.0199	1.41	Extracellular	Protease inhibitor
Nuclear receptor co-activator 6	Q14686	0.0307	1.33	Nucleus	Transcriptional regulation
Plasma retinol-binding protein precursor	P02753	0.0356	1.30	Extracellular	Transporter
Retinoblastoma-binding protein 1	P29374	0.0361	1.43	Nucleus	Transcriptional regulation
Apolipoprotein C-III precursor	P02656	0.0395	1.29	Extracellular	Transporter
Kallistatin precursor	P29622	0.0461	1.19	Extracellular	Peptidase inhibitor
Down-Regulated:
Coagulation factor XII precursor	P00748	0.0017	0.76	Extracellular	Coagulation
Peroxisomal carnitine octanoyl transferase	Q9UKG9	0.0196	0.67	Peroxisome	Metabolism fatty acid
Ficolin 3 precursor	NP_003656	0.0218	0.83	Extracellular	Immune response
Fibrinogen C	NP_116232	0.0248	0.83	Extracellular	Coagulation
Probable ATP-dependent helicase DHX37	Q8IY37	0.0253	0.89	Nucleus	RNA helicase
Polycystin 1 precursor	P98161	0.0341	0.78	Plasma membrane	Transporter/Signaling
Complement C1q A chain precursor	P02745	0.0350	0.69	Extracellular	Immune response
NK cell receptor 3DL1 precursor	P43629	0.0368	0.85	Plasma membrane	Immune response
Serum paraoxonase/arylesterase 1	P27169	0.0381	0.75	Extracellular	Detoxification/anti-oxidation
*Unaffected Twins vs. Unrelated, Matched Controls*
*Up-Regulated:*
Apolipoprotein C-IV precursor	P55056	0.0436	1.38	Extracellular	Transporter
Apolipoprotein C-III precursor	P02656	0.0493	1.24	Extracellular	Transporter
Histone deacetylase 3	O15379	0.0494	1.12	Nucleus	Chromatin modulation
Down-Regulated:
Alpha-1-antichymotrypsin precursor	P01011	0.0036	0.84	Extracellular	Protease inhibitor
Fibrinogen C	NP_116232	0.0046	0.78	Extracellular	Coagulation
Ficolin 3 precursor	NP_003656	0.0049	0.80	Extracellular	Immune response
Keratin type II	P35908	0.0232	0.87	Cytoplasm	Structural
Syntaxin 17	P56962	0.0311	0.85	Plasma membrane	Vesicular transport
Serum paraoxonase/arylesterase 1	P27169	0.0466	0.69	Extracellular	Detoxification/anti-oxidation

*Abbreviations: No., number; Exp., expression
**protein-protein interaction; cell adhesion; signal transduction; granulocyte differentiation

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