Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways

Table 2 Association of adiponectin and radiographic severity of osteoarthritis

	Ahlbäck grades 4 and 5			Ahlbäck grades 1 to 3
Patient characteristics	Crude OR	95% CI	P-values	Adjusted OR	95% CI	P-values
Plasma adiponectin (μg/ml)	2.2	1.1 to 4.3	0.022	2.2^a	1.1 to 4.4	0.022
				1.9^b	0.9 to 3.8	0.090
Culture media adiponectin (pg/mg cartilage)	1.1	1.0 to 1.2	0.007	1.1^a	1.0 to 1.2	0.007
				1.1^b	1.0 to 1.2	0.016
BMI (kg/m²)	1.0	0.8 to 1.2	0.852
Age (years)	1.1	1.0 to 1.3	0.078

^aAdjusted for BMI. ^bAdjusted for age. Odds ratios are given for Ahlbäck grades 4 and 5 group vs grades 1 to 3 group.

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