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Table 2 Heart rate variability indexes in 22 female patients with fibromyalgia and 22 matched healthy controls.

From: Nocturnal heart rate variability parameters as potential fibromyalgia biomarker: correlation with symptoms severity

  24-hour Sleeping hours
  Fibromyalgia Controls P value Fibromyalgia Controls P value
Mean NN (ms) 758.4 ± 70.9 796.5 ± 92.0 0.132 881.5 ± 94.8 915.6 ± 122.9 0.310
SDNN (ms) 133.7 ± 28.7 152.6 ± 32.8 0.047 91.2 ± 21.5 122.2 ± 32.0 0.001
SDANN (ms) 120.0 ± 28.1 132.5 ± 27.9 0.144 57.8 ± 19.2 83.2 ± 35.9 0.006
SDSD (ms) 36.0 ± 13.9 47.3 ± 16.9 0.020 45.9 ± 19.6 56.9 ± 21.3 0.084
RMSSD (ms) 36.0 ± 13.9 47.3 ± 16.9 0.020 45.9 ± 19.6 56.9 ± 21.3 0.084
pNN50 (%) 13.6 ± 10.3 20.5 ± 11.6 0.045 23.9 ± 17.5 31.4 ± 17.5 0.160
  1. Holter recordings were analyzed for 24 hours, and during sleeping time (from 00.00 to 06.00 hours). Results are shown as mean ± standard deviation. Student's t test calculated the differences between fibromyalgia group and control group. Mean NN, mean NN interval; ms, milliseconds; pNN50, percentage of adjacent pairs of R-R intervals that differ by more than 50 ms from each other in a given time period; RMSSD, Square root of the mean of the squares of differences between adjacent NN intervals; SDANN, mean standard deviation of the average NN intervals calculated over 5 minutes; SDNN, standard deviation of the NN intervals; SDSD, standard deviation of the successive NN differences;