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Figure 7 | Arthritis Research & Therapy

Figure 7

From: Interleukin-1, tumor necrosis factor-alpha, and transforming growth factor-beta 1 and integrative meniscal repair: influences on meniscal cell proliferation and migration

Figure 7

IL-1 and TNF-α decreased cell proliferation at the surface interface of the meniscal repair explants. (A) Schematic of a meniscal repair explant, indicating the surface interface of the tissue that was analyzed in pink, which included the interface and 50 μm of tissue on either side of the interface. Representative confocal images of the surface interface of (B) inner or (C) outer zone meniscal repair explants that were treated with 0, 10 ng/mL IL-1, 10 ng/mL TNF-α, or 10 ng/mL TGF-β1 for 14 days. In the confocal images, cells that have proliferated are yellow and all cells are labeled red. The scale bar is equal to 100 μm. Inner and outer zone explants were treated with control media and (D) 10 ng/mL IL-1, (E) 10 ng/mL TNF-α, or (F) 10 ng/mL TGF-β1 for 14 days. The data are graphed as a percentage of proliferated cells at the surface interface of the tissue + standard error. *: P < 0.005 compared to control.

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