The results of serum MMP-3 level in all groups. A significantly higher serum MMP-3 level was found in the HIR group than that in the SED group. However, serum MMP-3 level decreased with the treatment of the MMP-3 inhibitor. Statistical significance was found in the HIRI2 group compared with the HIR group. * P < 0.05 compared to the SED group; # P < 0.05 compared to the HIR group.