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Table 3 Baseline characteristics of female OA patients according to serum FSTL1 levels.

From: Follistatin-like protein 1: a serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis

  Female serum FSTL1 levels (μg/L)   
  First quartile Second quartile Third quartile Fourth quartile P r
  (1.94-15.65) (15.65-24.35) (24.45-31.08) (31.20-54.20)   
Number 30 30 30 30   
Age (years) 62 (52-67) 66 (58-72) 62 (56-70) 61 (54-65) 0.592 0.049
Disease duration (years) 1 (0.5-3.0) 1 (0.2-6.3) 1.5 (0.5-3.6) 2 (0.5-8.5) 0.282 0.099
Height, cm 160 (155-164) 158 (156-162) 158 (158-162) 158 (155-162) 0.049 -0.181
Weight, kg 65 (60-70) 62 (55-70) 65 (60-70) 60 (55-65) 0.272 -0.101
BMI 25.3 (22.9-27.1) 25.1 (22.0-28.1) 25.8 (24.3-27.5) 23.9 (22.6-26.1) 0.667 -0.040
Single/dual knee (hip) 22/8 21/9 21/9 22/8 0.795 0.024
Hypertension 10 (33%) 9 (30%) 12 (40%) 6 (20%) 0.309 -0.094
Diabetes 5 (17%) 2 (7%) 6 (20%) 2 (7%) 0.894 -0.012
Hs-CRP (mg/L) 1.4 (0.6-4.1) 2.2 (1.1-4.7) 1.9 (1.0-4.6) 1.9 (0.9-11.3) 0.113 0.146
ESRa 13 (6-26) 11 (8-20) 10 (7-20) 11 (5-20) 0.270 -0.114
RF 6.9 (2.7-12.9) 8.6 (2.8-14.6) 7.3 (3.1-12.7) 7.7 (3.5-14.6) 0.910 0.010
Pain (VAS mm)b 60 (50-70) 60 (50-78) 55 (40-78) 50 (36-70) 0.166 -0.143
WOMAC score (all normalized/100)c      
Pain subscale 57 (50-61) 57 (48-70) 50 (46-64) 61 (53-71) 0.129 0.177
Stiffness subscale 47 (42-56) 50 (38-61) 58 (42-71) 64 (52-73) 0.015 0.279
Function subscale 56 (52-68) 59 (50-68) 63 (48-77) 73 (58-90) 0.079 0.204
Total Score 56 (48-63) 56 (48-66) 61 (46-73) 68 (56-78) 0.051 0.214
KL grade (0-4) 6/7/13/1/3 0/5/8/7/10 0/4/10/10/6 0/6/2/11/11 <0.0001 0.406
JSN 4 (13%) 17 (57%) 16 (53%) 22 (73%) <0.0001 0.419
  1. Data are number (%) or median (25th to 75th percentile). Linear regression was used to evaluate the relationships between FSTL1 levels and baseline characteristics and to calculate P values and the correlation coefficient, r. (Disease duration, hs-CRP, ESR and RF in the female OA patients were not normally distributed and were entered as ln-transformed variables). aData from ESR were available for 95 patients; bData from Pain VAS were available for 95 patients; cData from the total WOMAC score were available for 84 patients, and the pain subscale, stiffness subscale and function subscale were available for 75 patients, respectively. BMI, body mass index; ESR, erythrocyte sedimentation rate; FSTL1, follistatin-like protein 1; Hs-CRP, high sensitivity C-reactive protein; JSN, joint space narrowing; KL, Kellgren and Lawrence; OA, osteoarthritis; RF, rheumatoid factor; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities.