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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes

Figure 6

Network analysis of differentially expressed proteins using the IPA software. Proteins of WS that were found to be significantly different among pSS, non-SS sicca syndrome, RA-sSS and SSc-sSS syndromes were analysed by using IPA. (A) This network shows 35 proteins that work together for Cellular Movement, Haematological System Development and Function, Haematopoiesis. Ten of these 35 proteins were found in our salivary proteome. Protein-to-protein direct (solid lines) or indirect (dashed lines) interactions/regulations, based on information published in the literature are shown in the figure. In the panel B, the top 17 functions of the proteins identified in the network are shown. Proteins were matched to 72 functions with significance above 1.83 (P <0.015). The top 17 functions involving the 35 proteins are shown here with the number of associated proteins that were identified for each function. ACTB, actin beta; ALB, albumin, B2M, beta2microglobulin; CLEC11A, C-type lectin domain family 11 member A; COPS5, COP9 signalosome complex subunit 5; CTSC, cathepsin C; CXCL16, C-X-C motif chemokine 16; CXCL3, C-X-C motif chemokine 3; DLEU1, Leukemia-associated protein 1; ENO1, Alpha-enolase; FABP5, fatty acid-binding protein, epidermal; FCGR1C, putative high affinity immunoglobulin gamma Fc receptor IC; FCGRT, IgG receptor FcRn large subunit p51; FST, follistatin; GSTP1, glutathione S-transferase P; IFN-β1, interferon beta; IgG, immunoglobulin G; IL1F8, interleukin 1 family, member 8; IL8, interleukin 8; JNK, c-Jun N-terminal kinase; LNB, Lymphotoxin beta; MYC, v-myc myelocytomatosis viral oncogene homolog (avian); NFkB (complex), nuclear factor NF-kappa-B; PPP1R15A, protein phosphatase 1 regulatory subunit 15A; PTAFR, platelet-activating factor receptor; RND3, rho-related GTP-binding protein RhoE; S100A7, psoriasin 1; S100 A8, protein S100-A8; S100A9, protein S100-A9; SERPINB1, leukocyte elastase inhibitor; TAPBP, tapasin-related protein; TBP, TATA box binding protein; TNF, tumor necrosis factor; TNFAIP3, tumor necrosis factor, alpha-induced protein 3; TNFSF15, tumor necrosis factor ligand superfamily member

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