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Table 1 Primary, secondary SS and non-SS sicca patients' demographic and clinical features

From: Proteomic analysis of saliva: a unique tool to distinguish primary Sjögren's syndrome from secondary Sjögren's syndrome and other sicca syndromes

Data pSS (40) Sicca non-SS (10) RA-sSS (8) SSc-sSS (7)
Sex 40 F:0M 10 F:0M 8 F:0 M 7F:0M
Age (yrs) 52.4 ± 10.5 56.0 ± 10.7 60.8 ± 11.4 61.7 ± 8.1
Disease duration (yrs) 7 ± 6 3 ± 2 9 ± 7 7 ± 4
Oral symptoms 98% 80% 100% 86%
Ocular symptoms 97% 80% 100% 100%
Ocular tests (1) 100% 70% 100% 100%
Difficult in swallowing 19% 2% 12% 71%
Salivary gland enlargement 32% none 12% none
Minor salivary gland biopsy grading:     
Chisolm and Mason grade 0, 1, 2 None 10/10 5/8 1/7
   Chisolm and Mason grade 3 20/40 none 3/8 5/7
   Chisolm and Mason grade 4 20/40 none none 1/7
Arthralgia 76% 1% 100% 57%
Arthritis 6% none 100% none
Fatigue 73% 30% 25% 29%
Raynaud's phenomenon 43% 2% 12% 100%
Skin involvement 16% none 37% 14%
Dyspareunia 32% 2% none 14%
Interstitial lung disease None none 12% 14%
Peripheral nervous involvement 3% none 12% none
Kidney involvement 3% none none none
Leucopenia 30% none 12% 14%
Low C3 and/or C4 levels 33% 1% 12% 14%
Hypergammaglobulinemia 62% none 37% none
Antinuclear antibodies 94% 90% 62% 100%
Anti-Ro/SSA 70%/ none 25% 14%
Anti-La/SSB 36% none 12% none
Rheumatoid Factor 80% 2% 100% 29%
  1. (1), Schirmer's test and/or Lissamine Green; pSS, primary Sjögren's syndrome; RA-sSS secondary Sjögren's syndrome concomitant to rheumatoid arthritis; SS: Sjögren's syndrome; SSc: systemic sclerosis; SSc-sSS secondary Sjögren's syndrome concomitant to systemic sclerosis; sSS: secondary Sjögren's syndrome