42 family members were interviewed and examined for signs and symptoms of MWS. Symptomatic family members are depicted in grey, asymptomatic members in white. All 13 clinically symptomatic patients are carriers of the NLRP3 E311K mutation (grey). Asymptomatic family members, who were not genetically tested, are marked in stripes. Clinical status of the deceased great-grandparents generation (X) was reported by children (one affected, one asymptomatic).