Osteophyte analysis of knee joints after meniscal-ligamentous injury (MLI) as a function of diet. (a) A representative osteophyte in a histologic section from an MLI-treated knee of an HF mouse is shown (boxed area). (b) Average osteophyte diameters on the tibial surface were measured by using digitally projected images of the histologic slides. Results are expressed as the mean ± SEM from at least six mice, with three slides per mouse. A representative osteophyte (boxed area) in a histologic section from a sham-operated knee of an HF mouse (c) and a comparable location in an unaffected lean diet control (d) are shown. ×100 magnification. **P < 0.01. n = 6 to 8 mice in each group.