Type I interferon pathway in adult and juvenile dermatomyositis

Table 2 Interferon-regulated chemokines and other cytokines in adult and juvenile dermatomyositis subgroups compared with controls

	Healthy controls		Adult DM subjects			Juvenile DM subjects
	Median (n= 26)	95% CI	Median (n= 56)	95% CI	Pvalue	Median (n= 35)	95% CI	Pvalue
IFN gene score^a	6.5 (n = 20)	4.2 to 13.0	16.7 (n = 51)	8.6 to 29.9	0.006	18.8 (n = 32)	10.3 to 52.0	0.001
IFN chemokine score^b	3.9	2.8 to 4.5	19.1	10.2 to 27.8	<0.0001	19.2	12.9 to 36.8	<0.0001
IP-10^c	40.4	34.1 to 47.1	1066.9	240.2 to 1816.2	<0.0001	881.9	427.9 to 2328.7	<0.0001
ITAC	29.0	22.6 to 39.6	202.6	101.0 to 376.0	<0.0001	190.8	112.3 to 593.2	<0.0001
MCP-1	339.1	280.3 to 430.6	954.8	630.9 to 1293.6	<0.0001	850.3	749.2 to 1285.5	<0.0001
Other chemokines and cytokines
MIP-1β	180.9	163.2 to 208.3	179.1	149.2 to 219.5	0.808	207.8	168.2 to 250	0.301
MIG	15.7	12.0 to 18.7	100.0	60.57 to 143.6	<0.0001	80.1	44.7 to 128.2	<0.0001
IL-6	1.1	1.2 to 1.5	3.4	2.5 to 5.6	<0.0001	5.3	3.2 to 9.5	<0.0001
IL-8	15.0	11.8 to 19.2	8.4	6.0 to 3.0	0.002	8.2	6.5 to 13.4	0.003
IL-10	2.3	1.6 to 5.4	1.7	1.1 to 2.8	0.082	3.2	1.3 to 6.7	0.903
TNFα	4.8	4.5 to 5.3	4.3	3.1 to 5.2	0.184	6.7	5.1 to 7.5	0.022

Significant P values (Mann-Whitney test P ≤ 0.05 for comparison against controls) presented in bold. CI, confidence interval; DM, dermatomyositis; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein. ^aCalculated using mean expression values of IFIT1, G1P2, and IRF7 measured by quantitative real-time RT-PCR. ^bCalculated using the normalized mean of IP-10, I-TAC, and MCP-1 levels in serum. ^cProtein levels are expressed as pg/ml.

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