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Table 2 Interferon-regulated chemokines and other cytokines in adult and juvenile dermatomyositis subgroups compared with controls

From: Type I interferon pathway in adult and juvenile dermatomyositis

  Healthy controls Adult DM subjects Juvenile DM subjects
  Median
(n= 26)
95% CI Median
(n= 56)
95% CI Pvalue Median
(n= 35)
95% CI Pvalue
IFN gene scorea 6.5 (n = 20) 4.2 to 13.0 16.7 (n = 51) 8.6 to 29.9 0.006 18.8
(n = 32)
10.3 to 52.0 0.001
IFN chemokine scoreb 3.9 2.8 to 4.5 19.1 10.2 to 27.8 <0.0001 19.2 12.9 to 36.8 <0.0001
IP-10c 40.4 34.1 to 47.1 1066.9 240.2 to 1816.2 <0.0001 881.9 427.9 to 2328.7 <0.0001
ITAC 29.0 22.6 to 39.6 202.6 101.0 to 376.0 <0.0001 190.8 112.3 to 593.2 <0.0001
MCP-1 339.1 280.3 to 430.6 954.8 630.9 to 1293.6 <0.0001 850.3 749.2 to 1285.5 <0.0001
Other chemokines and cytokines         
MIP-1β 180.9 163.2 to 208.3 179.1 149.2 to 219.5 0.808 207.8 168.2 to 250 0.301
MIG 15.7 12.0 to 18.7 100.0 60.57 to 143.6 <0.0001 80.1 44.7 to 128.2 <0.0001
IL-6 1.1 1.2 to 1.5 3.4 2.5 to 5.6 <0.0001 5.3 3.2 to 9.5 <0.0001
IL-8 15.0 11.8 to 19.2 8.4 6.0 to 3.0 0.002 8.2 6.5 to 13.4 0.003
IL-10 2.3 1.6 to 5.4 1.7 1.1 to 2.8 0.082 3.2 1.3 to 6.7 0.903
TNFα 4.8 4.5 to 5.3 4.3 3.1 to 5.2 0.184 6.7 5.1 to 7.5 0.022
  1. Significant P values (Mann-Whitney test P ≤ 0.05 for comparison against controls) presented in bold. CI, confidence interval; DM, dermatomyositis; IFN, interferon; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein. aCalculated using mean expression values of IFIT1, G1P2, and IRF7 measured by quantitative real-time RT-PCR. bCalculated using the normalized mean of IP-10, I-TAC, and MCP-1 levels in serum. cProtein levels are expressed as pg/ml.