TY - JOUR AU - Andersson, G. B. PY - 1999 DA - 1999// TI - Epidemiological features of chronic low-back pain JO - Lancet VL - 354 UR - https://doi.org/10.1016/S0140-6736(99)01312-4 DO - 10.1016/S0140-6736(99)01312-4 ID - Andersson1999 ER - TY - JOUR AU - Luoma, K. AU - Riihimaki, H. AU - Luukkonen, R. AU - Raininko, R. AU - Viikari-Juntura, E. AU - Lamminen, A. PY - 2000 DA - 2000// TI - Low back pain in relation to lumbar disc degeneration JO - Spine (Phila Pa 1976) VL - 25 UR - https://doi.org/10.1097/00007632-200002150-00016 DO - 10.1097/00007632-200002150-00016 ID - Luoma2000 ER - TY - JOUR AU - Holm, S. AU - Maroudas, A. AU - Urban, J. P. AU - Selstam, G. AU - Nachemson, A. PY - 1981 DA - 1981// TI - Nutrition of the intervertebral disc: solute transport and metabolism JO - Connect Tissue Res VL - 8 UR - https://doi.org/10.3109/03008208109152130 DO - 10.3109/03008208109152130 ID - Holm1981 ER - TY - JOUR AU - Diamant, B. AU - Karlsson, J. AU - Nachemson, A. PY - 1968 DA - 1968// TI - Correlation between lactate levels and pH in discs of patients with lumbar rhizopathies JO - Experientia VL - 24 UR - https://doi.org/10.1007/BF02146615 DO - 10.1007/BF02146615 ID - Diamant1968 ER - TY - JOUR AU - Nachemson, A. PY - 1969 DA - 1969// TI - Intradiscal measurements of pH in patients with lumbar rhizopathies JO - Acta Orthop Scand VL - 40 UR - https://doi.org/10.3109/17453676908989482 DO - 10.3109/17453676908989482 ID - Nachemson1969 ER - TY - JOUR AU - Zhao, C. Q. AU - Wang, L. M. AU - Jiang, L. S. AU - Dai, L. Y. PY - 2007 DA - 2007// TI - The cell biology of intervertebral disc aging and degeneration JO - Ageing Res Rev VL - 6 UR - https://doi.org/10.1016/j.arr.2007.08.001 DO - 10.1016/j.arr.2007.08.001 ID - Zhao2007 ER - TY - JOUR AU - Osada, R. AU - Ohshima, H. AU - Ishihara, H. AU - Yudoh, K. AU - Sakai, K. AU - Matsui, H. AU - Tsuji, H. PY - 1996 DA - 1996// TI - Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs JO - J Orthop Res VL - 14 UR - https://doi.org/10.1002/jor.1100140503 DO - 10.1002/jor.1100140503 ID - Osada1996 ER - TY - JOUR AU - Thompson, J. P. AU - Oegema, T. J. AU - Bradford, D. S. PY - 1991 DA - 1991// TI - Stimulation of mature canine intervertebral disc by growth factors JO - Spine VL - 16 UR - https://doi.org/10.1097/00007632-199103000-00001 DO - 10.1097/00007632-199103000-00001 ID - Thompson1991 ER - TY - JOUR AU - Le Maitre, C. L. AU - Hoyland, J. A. AU - Freemont, A. J. PY - 2007 DA - 2007// TI - Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile JO - Arthritis Res Ther VL - 9 UR - https://doi.org/10.1186/ar2275 DO - 10.1186/ar2275 ID - Le Maitre2007 ER - TY - JOUR AU - Burke, J. G. AU - Watson, R. W. AU - Conhyea, D. AU - McCormack, D. AU - Dowling, F. E. AU - Walsh, M. G. AU - Fitzpatrick, J. M. PY - 2003 DA - 2003// TI - Human nucleus pulposus can respond to a pro-inflammatory stimulus JO - Spine VL - 28 UR - https://doi.org/10.1097/01.BRS.0000103341.45133.F3 DO - 10.1097/01.BRS.0000103341.45133.F3 ID - Burke2003 ER - TY - JOUR AU - Ishii, T. AU - Tsuji, H. AU - Sano, A. AU - Katoh, Y. AU - Matsui, H. AU - Terahata, N. PY - 1991 DA - 1991// TI - Histochemical and ultrastructural observations on brown degeneration of human intervertebral disc JO - J Orthop Res VL - 9 UR - https://doi.org/10.1002/jor.1100090111 DO - 10.1002/jor.1100090111 ID - Ishii1991 ER - TY - JOUR AU - Thompson, J. P. AU - Pearce, R. H. AU - Schechter, M. T. AU - Adams, M. E. AU - Tsang, I. K. AU - Bishop, P. B. PY - 1990 DA - 1990// TI - Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc JO - Spine (Phila Pa 1976) VL - 15 UR - https://doi.org/10.1097/00007632-199005000-00012 DO - 10.1097/00007632-199005000-00012 ID - Thompson1990 ER - TY - JOUR AU - Urban, J. P. AU - Smith, S. AU - Fairbank, J. C. PY - 2004 DA - 2004// TI - Nutrition of the intervertebral disc JO - Spine (Phila Pa 1976) VL - 29 UR - https://doi.org/10.1097/01.brs.0000146499.97948.52 DO - 10.1097/01.brs.0000146499.97948.52 ID - Urban2004 ER - TY - JOUR AU - Roberts, S. AU - Urban, J. P. AU - Evans, H. AU - Eisenstein, S. M. PY - 1996 DA - 1996// TI - Transport properties of the human cartilage endplate in relation to its composition and calcification JO - Spine (Phila Pa 1976) VL - 21 UR - https://doi.org/10.1097/00007632-199602150-00003 DO - 10.1097/00007632-199602150-00003 ID - Roberts1996 ER - TY - JOUR AU - Urban, M. R. AU - Fairbank, J. C. AU - Etherington, P. J. AU - Loh, F. L. AU - Winlove, C. P. AU - Urban, J. P. PY - 2001 DA - 2001// TI - Electrochemical measurement of transport into scoliotic intervertebral discs in vivo using nitrous oxide as a tracer JO - Spine (Phila Pa 1976) VL - 26 UR - https://doi.org/10.1097/00007632-200104150-00028 DO - 10.1097/00007632-200104150-00028 ID - Urban2001 ER - TY - JOUR AU - Kauppila, L. I. PY - 1997 DA - 1997// TI - Prevalence of stenotic changes in arteries supplying the lumbar spine. A postmortem angiographic study on 140 subjects JO - Ann Rheum Dis VL - 56 UR - https://doi.org/10.1136/ard.56.10.591 DO - 10.1136/ard.56.10.591 ID - Kauppila1997 ER - TY - JOUR AU - Zeng, L. AU - Chen, R. AU - Liang, F. AU - Tsuchiya, H. AU - Murai, H. AU - Nakahashi, T. AU - Iwai, K. AU - Takahashi, T. AU - Kanda, T. AU - Morimoto, S. PY - 2009 DA - 2009// TI - Silent information regulator, Sirtuin 1, and age-related diseases JO - Geriatr Gerontol Int VL - 9 UR - https://doi.org/10.1111/j.1447-0594.2008.00504.x DO - 10.1111/j.1447-0594.2008.00504.x ID - Zeng2009 ER - TY - JOUR AU - Dali-Youcef, N. AU - Lagouge, M. AU - Froelich, S. AU - Koehl, C. AU - Schoonjans, K. AU - Auwerx, J. PY - 2007 DA - 2007// TI - Sirtuins: the 'magnificent seven', function, metabolism and longevity JO - Ann Med VL - 39 UR - https://doi.org/10.1080/07853890701408194 DO - 10.1080/07853890701408194 ID - Dali-Youcef2007 ER - TY - JOUR AU - Kim, E. J. AU - Um, S. J. PY - 2008 DA - 2008// TI - SIRT1: roles in aging and cancer JO - BMB Rep VL - 41 UR - https://doi.org/10.5483/BMBRep.2008.41.11.751 DO - 10.5483/BMBRep.2008.41.11.751 ID - Kim2008 ER - TY - JOUR AU - Takayama, K. AU - Ishida, K. AU - Matsushita, T. AU - Fujita, N. AU - Hayashi, S. AU - Sasaki, K. AU - Tei, K. AU - Kubo, S. AU - Matsumoto, T. AU - Fujioka, H. AU - Kurosaka, M. AU - Kuroda, R. PY - 2009 DA - 2009// TI - SIRT1 regulation of apoptosis of human chondrocytes JO - Arthritis Rheum VL - 60 UR - https://doi.org/10.1002/art.24864 DO - 10.1002/art.24864 ID - Takayama2009 ER - TY - JOUR AU - Gagarina, V. AU - Gabay, O. AU - Dvir-Ginzberg, M. AU - Lee, E. J. AU - Brady, J. K. AU - Quon, M. J. AU - Hall, D. J. PY - 2010 DA - 2010// TI - SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway JO - Arthritis Rheum VL - 62 UR - https://doi.org/10.1002/art.27369 DO - 10.1002/art.27369 ID - Gagarina2010 ER - TY - JOUR AU - Dvir-Ginzberg, M. AU - Gagarina, V. AU - Lee, E. J. AU - Hall, D. J. PY - 2008 DA - 2008// TI - Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.M803196200 DO - 10.1074/jbc.M803196200 ID - Dvir-Ginzberg2008 ER - TY - JOUR AU - Kwon, H. S. AU - Ott, M. PY - 2008 DA - 2008// TI - The ups and downs of SIRT1 JO - Trends Biochem Sci VL - 33 UR - https://doi.org/10.1016/j.tibs.2008.08.001 DO - 10.1016/j.tibs.2008.08.001 ID - Kwon2008 ER - TY - JOUR AU - Pfirrmann, C. W. AU - Metzdorf, A. AU - Zanetti, M. AU - Hodler, J. AU - Boos, N. PY - 2001 DA - 2001// TI - Magnetic resonance classification of lumbar intervertebral disc degeneration JO - Spine (Phila Pa 1976) VL - 26 UR - https://doi.org/10.1097/00007632-200109010-00011 DO - 10.1097/00007632-200109010-00011 ID - Pfirrmann2001 ER - TY - JOUR AU - Sakai, D. AU - Nakai, T. AU - Mochida, J. AU - Alini, M. AU - Grad, S. PY - 2009 DA - 2009// TI - Differential phenotype of intervertebral disc cells: microarray and immunohistochemical analysis of canine nucleus pulposus and anulus fibrosus JO - Spine (Phila Pa 1976) VL - 34 UR - https://doi.org/10.1097/BRS.0b013e3181a55705 DO - 10.1097/BRS.0b013e3181a55705 ID - Sakai2009 ER - TY - JOUR AU - Livak, K. J. AU - Schmittgen, T. D. PY - 2001 DA - 2001// TI - Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method JO - Methods VL - 25 UR - https://doi.org/10.1006/meth.2001.1262 DO - 10.1006/meth.2001.1262 ID - Livak2001 ER - TY - STD TI - ImageJ. [http://rsbweb.nih.gov/ij/] UR - http://rsbweb.nih.gov/ij/ ID - ref27 ER - TY - JOUR AU - Alcendor, R. R. AU - Gao, S. AU - Zhai, P. AU - Zablocki, D. AU - Holle, E. AU - Yu, X. AU - Tian, B. AU - Wagner, T. AU - Vatner, S. F. AU - Sadoshima, J. PY - 2007 DA - 2007// TI - Sirt1 regulates aging and resistance to oxidative stress in the heart JO - Circ Res VL - 100 UR - https://doi.org/10.1161/01.RES.0000267723.65696.4a DO - 10.1161/01.RES.0000267723.65696.4a ID - Alcendor2007 ER - TY - JOUR AU - Li, J. AU - Wang, E. AU - Rinaldo, F. AU - Datta, K. PY - 2005 DA - 2005// TI - Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway JO - Oncogene VL - 24 UR - https://doi.org/10.1038/sj.onc.1208693 DO - 10.1038/sj.onc.1208693 ID - Li2005 ER - TY - JOUR AU - Chong, Z. Z. AU - Lin, S. H. AU - Li, F. AU - Maiese, K. PY - 2005 DA - 2005// TI - The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated 'anti-apoptotic' pathways JO - Curr Neurovasc Res VL - 2 UR - https://doi.org/10.2174/156720205774322584 DO - 10.2174/156720205774322584 ID - Chong2005 ER - TY - JOUR AU - Li, Y. AU - Xu, W. AU - McBurney, M. W. AU - Longo, V. D. PY - 2008 DA - 2008// TI - SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons JO - Cell Metab VL - 8 UR - https://doi.org/10.1016/j.cmet.2008.05.004 DO - 10.1016/j.cmet.2008.05.004 ID - Li2008 ER - TY - JOUR AU - Fujita, N. AU - Matsushita, T. AU - Ishida, K. AU - Kubo, S. AU - Matsumoto, T. AU - Takayama, K. AU - Kurosaka, M. AU - Kuroda, R. PY - 2011 DA - 2011// TI - Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions JO - J Orthop Res VL - 29 UR - https://doi.org/10.1002/jor.21284 DO - 10.1002/jor.21284 ID - Fujita2011 ER - TY - JOUR AU - Lee, R. B. AU - Urban, J. P. PY - 1997 DA - 1997// TI - Evidence for a negative Pasteur effect in articular cartilage JO - Biochem J VL - 321 UR - https://doi.org/10.1042/bj3210095 DO - 10.1042/bj3210095 ID - Lee1997 ER - TY - JOUR AU - Ishihara, H. AU - Urban, J. P. PY - 1999 DA - 1999// TI - Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc JO - J Orthop Res VL - 17 UR - https://doi.org/10.1002/jor.1100170607 DO - 10.1002/jor.1100170607 ID - Ishihara1999 ER - TY - JOUR AU - Urban, J. P. PY - 2002 DA - 2002// TI - The role of the physicochemical environment in determining disc cell behaviour JO - Biochem Soc Trans VL - 30 UR - https://doi.org/10.1042/bst0300858 DO - 10.1042/bst0300858 ID - Urban2002 ER - TY - JOUR AU - Miller, J. A. AU - Schmatz, C. AU - Schultz, A. B. PY - 1988 DA - 1988// TI - Lumbar disc degeneration: correlation with age, sex, and spine level in 600 autopsy specimens JO - Spine (Phila Pa 1976) VL - 13 UR - https://doi.org/10.1097/00007632-198802000-00008 DO - 10.1097/00007632-198802000-00008 ID - Miller1988 ER - TY - JOUR AU - Sowa, G. AU - Vadala, G. AU - Studer, R. AU - Kompel, J. AU - Iucu, C. AU - Georgescu, H. AU - Gilbertson, L. AU - Kang, J. PY - 2008 DA - 2008// TI - Characterization of intervertebral disc aging: longitudinal analysis of a rabbit model by magnetic resonance imaging, histology, and gene expression JO - Spine (Phila Pa 1976) VL - 33 UR - https://doi.org/10.1097/BRS.0b013e31817e2ce3 DO - 10.1097/BRS.0b013e31817e2ce3 ID - Sowa2008 ER - TY - JOUR AU - Kauppila, L. I. PY - 1995 DA - 1995// TI - Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of cadaveric spines JO - J Bone Joint Surg Am VL - 77 ID - Kauppila1995 ER - TY - JOUR AU - Masuda, K. AU - Oegema, T. R. AU - An, H. S. PY - 2004 DA - 2004// TI - Growth factors and treatment of intervertebral disc degeneration JO - Spine (Phila Pa 1976) VL - 29 UR - https://doi.org/10.1097/01.brs.0000146048.14946.af DO - 10.1097/01.brs.0000146048.14946.af ID - Masuda2004 ER - TY - JOUR AU - Sakai, D. AU - Mochida, J. AU - Yamamoto, Y. AU - Nomura, T. AU - Okuma, M. AU - Nishimura, K. AU - Nakai, T. AU - Ando, K. AU - Hotta, T. PY - 2003 DA - 2003// TI - Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration JO - Biomaterials VL - 24 UR - https://doi.org/10.1016/S0142-9612(03)00222-9 DO - 10.1016/S0142-9612(03)00222-9 ID - Sakai2003 ER - TY - JOUR AU - Boos, N. AU - Weissbach, S. AU - Rohrbach, H. AU - Weiler, C. AU - Spratt, K. F. AU - Nerlich, A. G. PY - 2002 DA - 2002// TI - Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science JO - Spine (Phila Pa 1976) VL - 27 UR - https://doi.org/10.1097/00007632-200212010-00002 DO - 10.1097/00007632-200212010-00002 ID - Boos2002 ER - TY - JOUR AU - Sudo, H. AU - Minami, A. PY - 2011 DA - 2011// TI - Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits JO - Arthritis Rheum VL - 63 UR - https://doi.org/10.1002/art.30251 DO - 10.1002/art.30251 ID - Sudo2011 ER -