Table 1 Morphometric parameters of tibial subchondral trabecular bone in the MIA-injected tibiae and in the control tibiae, at 2, 6, and 10 weeks post-MIA injection

BV (mm ³ )

Medial

613 ± 97

745 ± 118

-17.8

0.018

1177 ± 211

993 ± 214

18.6

0.102

1481 ± 271

1179 ± 229

25.6

0.102

Lateral

647 ± 120

711 ± 130

-9.0

0.116

1145 ± 168

948 ± 169

20.7

0.116

1229 ± 133

1205 ± 241

2.0

0.709

Total

1260 ± 202

1456 ± 239

-13.5

0.048

2322 ± 341

1941 ± 370

19.7

0.098

2710 ± 326

2384 ± 454

13.7

0.116

BV/TV (%)

Medial

16.8 ± 2.6

20.4 ± 3.2

-18.0

0.018

32.7 ± 6.5

27.5 ± 6.6

19.1

0.156

39.8 ± 7.7

33.6 ± 7.6

18.5

0.156

Lateral

15.1 ± 2.8

16.7 ± 3.0

-9.1

0.156

27.2 ± 3.6

22.2 ± 3.8

22.5

0.156

29.0 ± 3.2

28.2 ± 6.0

3.0

0.592

Total

15.9 ± 2.5

18.6 ± 3.0

-14.0

0.032

30.0 ± 4.2

24.8 ± 5.0

20.6

0.154

34.4 ± 4.8

30.9 ± 6.4

11.5

0.156

Tb.Th (μm)

Medial

94 ± 5

92 ± 3

2.1

0.396

124 ± 11

100 ± 9

24.6

p < 0.001

149 ± 19

110 ± 12

34.9

0.001

Lateral

89 ± 4

87 ± 3

1.6

0.360

117 ± 9

95 ± 5

23.1

0.001

128 ± 17

105 ± 8

22.0

0.012

Total

91 ± 4

90 ± 3

1.9

0.396

120 ± 9

97 ± 7

23.9

p < 0.001

138 ± 18

108 ± 10

28.6

0.002

Tb.N (1/mm)

Medial

1.8 ± 0.3

2.2 ± 0.3

-19.9

0.009

2.5 ± 0.5

2.7 ± 0.5

-9.5

0.405

2.6 ± 0.5

3.1 ± 0.4

-13.7

0.112

Lateral

1.7 ± 0.3

1.9 ± 0.3

-12.2

0.020

2.2 ± 0.3

2.3 ± 0.3

-6.8

0.405

2.3 ± 0.3

2.7 ± 0.3

-16.0

0.009

Total

1.7 ± 0.2

2.1 ± 0.3

-16.3

0.009

2.3 ± 0.3

2.5 ± 0.4

-8.3

0.405

2.5 ± 0.3

2.9 ± 0.4

-14.8

0.012

Tb.Sp (μm)

Medial

270 ± 16

243 ± 17

10.8

p < 0.001

240 ± 19

203 ± 24

17.9

0.002

241 ± 32

207 ± 20

16.3

0.005

Lateral

272 ± 16

256 ± 17

6.2

0.001

250 ± 16

221 ± 14

13.2

0.001

258 ± 17

223 ± 15

15.7

p < 0.001

Total

271 ± 13

250 ± 14

8.4

p < 0.001

245 ± 15

212 ± 16

15.5

0.001

245 ± 22

215 ± 15

13.8

0.001