Time interval between systemic sclerosis onset and diagnosis of malignancy. Systemic sclerosis (SSc) onset was defined based on onset of skin change. Symbols to the left of the vertical line (denoting time = 0 years) represent malignancies diagnosed prior to the onset of SSc. Solid organ malignancies include breast, lung, colorectal, genitourinary and reproductive tract malignancies. Hematopoeitic malignancies include lymphoma, leukemia and multiple myeloma. Nonmelanoma skin cancers include basal cell and squamous cell carcinomas. The 'other' category includes neoplastic variants and pre-neoplastic disorders. RNAP, anti-RNA polymerase III antibody.