Figure 4

Pain behavioral responses to treatment with A-803467. In (A), MIA causes a profound shift in hindlimb weight distribution onto the unaffected hindlimb. Following A-803467 treatment body weight was re-distributed onto the MIA-treated joint reflecting an analgesic effect. In (B), hindpaw withdrawal thresholds were measured in response to an intra-articular injection of A-803467. The force required to elicit hindpaw withdrawal following A-803467 was significantly reduced compared to vehicle-treated animals, confirming a reduction in MIA induced secondary allodynia. Values are means ± SEM.