Table 3 Proteins newly identified in OA synovial fluids

Zinc-α₂-glycoprotein

P25311

140.54

35

10

Ig α1 chain C region

P01876

128.82

37

9

Ig γ-1 chain C region

P01857

115.3

35

9

Ig κ chain C region

P01834

87.06

85

6

Calgranulin A (MRP-8)

P05109

67.87

33

5

Collagen α₁(I) chain

P02452

40.14

4

4

Complement component C9

P02748

36.76

9

4

Serum paraoxonase/arylesterase 1

P27169

34.77

13

3

Ig κ chain V-III region SIE

P01620

33.65

38

3

Ig heavy-chain V-III region BRO

P01766

28.94

24

2

NF-κB-repressing factor

O15226

23.76

8

3

A-kinase anchor protein-like protein 8

Q9ULX6

23.65

11

3

Structural maintenance of chromosomes 4-like 1 protein

Q9NTJ3

23.43

1

2

Bromodomain adjacent to zinc-finger domain 2B (hWALp4)

Q9UIF8

22.6

3

3

Histone deacetylase 5

Q9UQL6

22.4

4

3

Voltage-dependent R-type calcium channel α-1E subunit

Q15878

22.29

1

2

Inhibitor of nuclear factor κB kinase β subunit

O14920

22.07

8

3

β platelet-derived growth factor receptor precursor (EC 2.7.1.112) (CD140b antigen)

P09619

20.93

5

2

Leucine-rich α₂-glycoprotein

P02750

20.55

5

2

Mitochondrial 28S ribosomal protein S29

P51398

19.76

6

2

Glucose-6-phosphate 1-dehydrogenase

P11413

19.58

14

3

Collagen α₂(I) chain

P08123

18.98

7

3

Histone H4

P62805

18.73

16

2

Macrophage inflammatory protein 2-β

P19876

18.72

28

2

Collagen α₃(IV) chain

Q01955

18.15

5

2

Histone-lysine N-methyltransferase, H3 lysine-9 specific 4

Q15047

17.82

4

2

Toll-like receptor 6

Q9Y2C9

17.38

2

2

Nuclear factor NF-κB p100 subunit

Q00653

17.22

7

2

Possible global transcription activator SNF2L1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)

P28370

16.37

5

2

RRP5 protein homologue

Q14690

16.35

3

2

Interleukin-20 receptor α chain

Q9UHF4

16.22

11

2

NF-κB inhibitor-like protein 1

Q9UBC1

16.13

14

2

Platelet endothelial cell-adhesion molecule

P16284

15.87

10

2

Fibroblast growth factor receptor 2

P21802

15.4

2

2

Interleukin-1 receptor-associated kinase 1

P51617

14.92

11

2

Cadherin EGF LAG seven-pass G-type receptor 1

Q9NYQ6

14.84

1

2

Collagen α₂(V) chain

P05997

14.78

5

2

Zinc-finger A20 domain-containing protein 1

Q6GQQ9

14.61

6

2

Low-density lipoprotein receptor-related protein 1 (apolipoprotein E receptor)

Q07954

14.54

1

2

Microtubule-actin crosslinking factor 1, isoforms 1/2/3/5

Q9UPN3

14.53

1

2

Zinc-finger DHHC domain-containing protein 13

Q8IUH4

14.48

11

2

Death-associated protein kinase 1

P53355

14.41

3

2

Collagen α₁(V) chain

P20908

13.78

4

2

Integrin α-V (Vitronectin receptor α subunit)

P06756

13.52

3

2

Misshapen-like kinase 1(MAPK/ERK kinase kinase kinase 6)

Q8N4C8

13.36

4

2

Cadherin EGF LAG seven-pass G-type receptor

Q9NYQ7

13.26

1

3

Regulator of G-protein signaling 14

O43566

13.21

8

2

Collagen α₁(VII) chain

Q02388

13.19

1

2

Interleukin-12 receptor β₂ chain

Q99665

13.1

5

2

Interleukin-1β (IL-1β)

P01584

12.94

20

2

Platelet-derived growth factor B chain

P01127

12.91

18

2

Collagen α₁(II) chain

P02458

12.65

6

2

Pappalysin-1

Q13219

12.58

2

2

Complement C1q tumor necrosis factor-related protein 5

Q9BXJ0

11.97

23

2

Interleukin-18 receptor 1 precursor (IL-1 receptor-related protein)

Q13478

11.8

4

2

A kinase anchor protein 10, mitochondrial (PRKA10)

O43572

11.36

8

2

Neutrophil collagenase

P22894

11.34

9

2

Protein-arginine deiminase type I

Q9ULC6

11.34

5

2

TNF receptor-associated factor 5 (RING finger protein 84)

O00463

10.92

8

2

Macrophage receptor MARCO

Q9UEW3

10.89

8

2

Collagen α₃(V) chain

P25940

10.32

1

2

Histone acetyltransferase MYST3

Q92794

10.14

2

2

Leukocyte immunoglobulin-like receptor subfamily B member 4

Q8NHJ6

9.43

11

2

Mast/stem cell growth-factor receptor

P10721

9.3

5

2