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Table 3 Proteins newly identified in OA synovial fluids

From: Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Protein namea Accession no.b Scorec % Coveraged No. of peptidese
Zinc-α2-glycoprotein P25311 140.54 35 10
Ig α1 chain C region P01876 128.82 37 9
Ig γ-1 chain C region P01857 115.3 35 9
Ig κ chain C region P01834 87.06 85 6
Calgranulin A (MRP-8) P05109 67.87 33 5
Collagen α1(I) chain P02452 40.14 4 4
Complement component C9 P02748 36.76 9 4
Serum paraoxonase/arylesterase 1 P27169 34.77 13 3
Ig κ chain V-III region SIE P01620 33.65 38 3
Ig heavy-chain V-III region BRO P01766 28.94 24 2
NF-κB-repressing factor O15226 23.76 8 3
A-kinase anchor protein-like protein 8 Q9ULX6 23.65 11 3
Structural maintenance of chromosomes 4-like 1 protein Q9NTJ3 23.43 1 2
Bromodomain adjacent to zinc-finger domain 2B (hWALp4) Q9UIF8 22.6 3 3
Histone deacetylase 5 Q9UQL6 22.4 4 3
Voltage-dependent R-type calcium channel α-1E subunit Q15878 22.29 1 2
Inhibitor of nuclear factor κB kinase β subunit O14920 22.07 8 3
β platelet-derived growth factor receptor precursor (EC 2.7.1.112) (CD140b antigen) P09619 20.93 5 2
Leucine-rich α2-glycoprotein P02750 20.55 5 2
Mitochondrial 28S ribosomal protein S29 P51398 19.76 6 2
Glucose-6-phosphate 1-dehydrogenase P11413 19.58 14 3
Collagen α2(I) chain P08123 18.98 7 3
Histone H4 P62805 18.73 16 2
Macrophage inflammatory protein 2-β P19876 18.72 28 2
Collagen α3(IV) chain Q01955 18.15 5 2
Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 Q15047 17.82 4 2
Toll-like receptor 6 Q9Y2C9 17.38 2 2
Nuclear factor NF-κB p100 subunit Q00653 17.22 7 2
Possible global transcription activator SNF2L1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) P28370 16.37 5 2
RRP5 protein homologue Q14690 16.35 3 2
Interleukin-20 receptor α chain Q9UHF4 16.22 11 2
NF-κB inhibitor-like protein 1 Q9UBC1 16.13 14 2
Platelet endothelial cell-adhesion molecule P16284 15.87 10 2
Fibroblast growth factor receptor 2 P21802 15.4 2 2
Interleukin-1 receptor-associated kinase 1 P51617 14.92 11 2
Cadherin EGF LAG seven-pass G-type receptor 1 Q9NYQ6 14.84 1 2
Collagen α2(V) chain P05997 14.78 5 2
Zinc-finger A20 domain-containing protein 1 Q6GQQ9 14.61 6 2
Low-density lipoprotein receptor-related protein 1 (apolipoprotein E receptor) Q07954 14.54 1 2
Microtubule-actin crosslinking factor 1, isoforms 1/2/3/5 Q9UPN3 14.53 1 2
Zinc-finger DHHC domain-containing protein 13 Q8IUH4 14.48 11 2
Death-associated protein kinase 1 P53355 14.41 3 2
Collagen α1(V) chain P20908 13.78 4 2
Integrin α-V (Vitronectin receptor α subunit) P06756 13.52 3 2
Misshapen-like kinase 1(MAPK/ERK kinase kinase kinase 6) Q8N4C8 13.36 4 2
Cadherin EGF LAG seven-pass G-type receptor Q9NYQ7 13.26 1 3
Regulator of G-protein signaling 14 O43566 13.21 8 2
Collagen α1(VII) chain Q02388 13.19 1 2
Interleukin-12 receptor β2 chain Q99665 13.1 5 2
Interleukin-1β (IL-1β) P01584 12.94 20 2
Platelet-derived growth factor B chain P01127 12.91 18 2
Collagen α1(II) chain P02458 12.65 6 2
Pappalysin-1 Q13219 12.58 2 2
Complement C1q tumor necrosis factor-related protein 5 Q9BXJ0 11.97 23 2
Interleukin-18 receptor 1 precursor (IL-1 receptor-related protein) Q13478 11.8 4 2
A kinase anchor protein 10, mitochondrial (PRKA10) O43572 11.36 8 2
Neutrophil collagenase P22894 11.34 9 2
Protein-arginine deiminase type I Q9ULC6 11.34 5 2
TNF receptor-associated factor 5 (RING finger protein 84) O00463 10.92 8 2
Macrophage receptor MARCO Q9UEW3 10.89 8 2
Collagen α3(V) chain P25940 10.32 1 2
Histone acetyltransferase MYST3 Q92794 10.14 2 2
Leukocyte immunoglobulin-like receptor subfamily B member 4 Q8NHJ6 9.43 11 2
Mast/stem cell growth-factor receptor P10721 9.3 5 2
  1. aShown in bold are the proteins classified as plasma proteins (as assessed by www.HPRD.org). bUniProtKB/Swiss-Prot database. cAn aggregate score of the quality of the peptide spectra obtained, the total number of peptides identified, and percentage coverage of the protein. dThe number of amino acids identified as a percentage of the total number of amino acids in the corresponding protein. eThe number of peptides identified that correspond to the protein indicated.