Skip to main content

Table 5 Absolute and relative cytokine levels in healthy and OA serum, and in OA synovial fluid

From: Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

Cytokine Normal serum levels (pg/ml)a OA serum levels (pg/ml)b OA SF levels (pg/ml)c Ratio of OA serum levels to normal serum levels Ratio of OA SF levels to OA serum levels
IL-6 3.02
(2.7-4.4)
5.13
(4.4-5.8)
975.39
(454.0-2,689.5)
1.7 190.1
IL-1β 1.22
(1.0-1.3)
1.58
(1.4-1.8)
1.14
(1.0-1.7)
1.3 0.7
TNF 0.00
(0.0-0.0)
0.00
(0.0-0.0)
2.92
(0.0-13.3)
- -
VEGF 20.53
(11.7-65.6)
78.22
(31.3-124.6)
496.31
(245.0-577.8)
3.8 6.3
MCP-1 3.59
(0.0-11.9)
18.53
(13.0-28.0)
107.67
(84.8-191.1)
5.2 5.8
IP-10 537.00
(376.1-750.4)
795.55
(684.7-1,029.7)
2,105.40
(923.2-4,913.3)
1.5 2.6
MIG 244.51
(173.5-374.6)
420.13
(308.4-568.6)
1,047.14
(389.8-1,925.3)
1.7 2.5
  1. OA, osteoarthritis; SF, synovial fluid; IL, interleukin; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; MCP-1, macrophage chemotactic protein 1; IP-10, interferon γ-induced protein 10; MIG, monokine-induced by interferon γ. aThe median (IQR); n = 34 healthy individuals. bThe median (IQR); n = 23 individuals with OA. cThe median (IQR); n = 10 individuals with OA.